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Molecular interactions involved in bacterial mitosis
Bacterial proliferation relies on a series of essential processes such as genome expression, replication, genome segregation and recombination. By contrast to most of them, the comprehension of genome
Molecular imaging of nicotinic alpha7 receptors in Alzheimer's disease
Alzheimer’s disease (AD) is the most frequent progressive neurodegenerative disease representing the major cause of dementia in elderly subject. With 860000 people affected in France, it is a major pu
Molecular cross-talks during commissural axon guidance in the developing spinal cord
The establishment of neuronal connectivity during embryonic life development is a complex and crucial process for the future integrity of the nervous system. Increasing evidence indicates that alterations of early processes of neural circuit formation contribute to several neurological diseases. Our project aims at identifying some new mechanisms regulating the navigation of neuronal projections and controlling the process of pathway selection.
Molecular characterisation of the assembly and functioning of a membrane complex: the NADPH-oxidase
The NADPH oxidase is a part of numerous membrane proteins of which the three-dimensional structure was not able yet to be determined in spite of numerous efforts in the development of the production and purification techniques. However the knowledge of its structure and its functioning stays a major stake due to its pharmacological importance. That is why since a few years our efforts aim at the elaboration of a system of effective production of this enzyme.
Molecular basis of the vectorial transport of sterol
Sterol is a key lipid whose distribution inside cells is guaranteed by transport mechanisms that are poorly documented. By discovering the ability of proteins to exchange sterol for a second lipid, PI(4)P, we have unveiled the existence of transport routes for the sterol that relies on the dissipation of the metabolic energy of PI(4)P between intracellular compartments.
Molecular bases of CXCR4 dysfunctions in rare immunodeficiency disorders
Our activities are focused on molecular and functional aspects of the relationship established between the chemokine SDF-1/CXCL12 and its receptors, particularly CXCR4, in two rare immunodeficiency di
Molecular and evolutive bases for the cell adhesion properties of some non-catalytic alpha/beta-hydrolases
Understand why some macromolecules that resemble enzymes of the alpa/beta hydrolase fold family are cell adhesion molecules, and how they function. Use these pieces of information to predict the function (enzyme or adhesion?) of newly identified members in the family.
Molecular and cellular regulation of beta1,4-GalNAcT-II in physiological and pathological states (gastrointestinal cancer)
This project aims at understanding the molecular and cellular mechanisms underlying the supramolecular organization and localization of Golgi-GTs implicated in the biosynthesis of Sda et sLex antigens
Molecular and cellular mechanisms of mechanotransduction and mechano-sensing at cell-cell junctions
Molecular and cellular mechanisms of mechanotransduction and mechano-sensing at cell-cell junctions
Molecular and cellular mechanisms of Meckel/Joubert ciliopathy
Meckel syndrome (MKS) is a severe autosomal recessive ciliopathy, which is often lethal prenatally or at birth, characterized by pleiotropic phenotypes such as multicystic kidney and hepatic duct dysp
