Sudden cardiac death (SCD) can be the first symptom of rare inherited arrhythmia disorders. Among these disorders, the Brugada syndrome and the early repolarization syndrome, or ‘J-wave syndromes’ (JWS), are highly amenable to genetic studies and can be used as models to yield molecular insights relevant to the broader problem of SCD.
A multi-disciplinary study of human beings, great apes and disease emergence in equatorial Africa: Social sciences perspectives on cross-species contacts – SHAPES
This multi-disciplinary study examined the changing nature of human contact with nonhuman primates in equatorial Africa and the health consequences of those contacts. To provide describe more fully this contact, its changing significance over the past 150 years, and its influence on human health, we examined human-primate engagements and the emergence of selected diseases. We developed multi-disciplinary understandings of past dynamics of disease emergence and new insights into future ones.
A multidimensional exploration of exoprotein transport and secretion by the type II secretion pathway – 4D-SECRETION
Pathogenic bacteria have developed highly sophisticated nano-machines to guarantee the efficient secretion of virulence factors. The type II secretion system (T2SS) is dedicated to the transport of fo
Our research project focuses on the development of new broad-spectrum antibiotics that target the main quality control mechanism of bacterial protein synthesis : trans- translation .
Innate immunity, an essential arm of the immune system, must be kept under tight control to avoid adverse effects to the host, such as immunodeficiency or autoimmunity. Although the metabolism of cellular nucleotides and DNA repair was recently linked to the regulation of innate immune responses, the mechanisms underlying its deregulation are unclear. It is crucial to identify such mechanisms to better understand some human pathologies.
Ensuring the availability of a given metal for growth is a vital microbial process, especially critical when the source becomes scarce like inside a host. Here, we present a project that is dedicated
A replay-driven model of spatial sequence learning in the Hippocampus-PFC network using reservoir computing – SPAQUENCE
In a complex environment, animals and humans learn to navigate between sequences of significant places. Such spatial sequence learning has been shown to involve brain areas including the hippocampus (
Autosomal dominant Centronuclear myopathy (CNM) is a rare neuromuscular disorder due to mutations in the DNM2 gene coding for Dynamin 2 (DNM2). We have demonstrated that the ubiquitous clathrin heavy
The main goal of the present project is to investigate both experimentally and theoretically the potential of a semiconductor spin-photon interface for quantum information processing. Our objectives r
AGuIX® theranostic nanoparticles for vascular-targeted interstitial photodynamic therapy of brain tumors – PhotoBrain
Photodynamic therapy (PDT) for brain tumors appears to be complementary to conventional treatments. Numerous studies show the major role of the vascular effect in PDT tumor eradication. For interstiti