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Transcriptional precision during development : the problematic case of nested genes – TransDev
During development, cell fate specification relies on transcriptional regulation. For development to be robust, the transcription of developmental genes has to be very precise. However, several genomi
Improved near-Wall flow Prediction integrating Immersed Boundary Method and Data Assimilation – IWP-IBM-DA
Owing to the ever-growing resources available at supercomputing centers, High Performance Computing (HPC) analyses of flow configurations including several complex concurring aspects are becoming an e
Transcription pre-initiation complex regulation by nutrient dependent O-GlcNAcylation of TATA-Box Binding Protein – TaNGoT
Gene expression is performed by three RNA polymerases (RNAPs) each of which is devoted to a specific class of gene. Assembly of specific molecular complexes at gene promoters to form pre-initiation co
Neural circuit dynamics underlying persistent active place avoidance. – NEURAVOID
Post-traumatic stress disorder (PTSD) is the fourth most prevalent psychiatric diagnosis encompassing three clusters of symptoms: re-experiencing the traumatic event, avoidance symptoms and hyper arou
Dissection of molecular and neural circuits underlying impulse control disorders: A translational approach – DISCOMMODE
Impulse control disorders (ICDs), for example gambling behaviors, hypersexuality or compulsive eating, are characterized by urges and excessive and uncontrolled behaviors, which ultimately can become
Reinforcement learning as optimal control for fluid flows – REASON
Environmental needs are invigorating research interest in many engineering fields. A compelling example is provided by carbon-dioxide emissions, widely considered one of the main causes of global warm
Monitoring of water quality and remediation: Innovative multifunctional micro-sensor – AQUAE
There is an urgent need to develop reliable and reproducible sensing technologies for in situ and continuous water monitoring for surface water and wastewaters. The AQUAE project will address this nee
Studying mealworm life history evolution to optimize its industrial production – OPTIM-INSECT
The mealworm beetle Tenebrio molitor is a promising alternative protein source for nutrition. Optimizing its mass production at an industrial scale requires a better knowledge of the evolution of the
Molecular Etiology and Epigenetic Landscape of Rahman Syndrome – RAHMAN
Germline frameshift mutations in one of the alleles of the linker histone H1E were causally linked to an as-yet poorly defined syndrome, called Rahman syndrome. Affected individuals exhibit characteri
Regulation of Mammalian Enhancers by DNA methylation – REMEDY
Cellular function depends on a precise pattern of gene expression, and alterations of this process are linked to human diseases. This pattern is determined by interactions between transcriptional regu
