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Novel mechanisms of Muscle maturation by proteolytic turnover of mTORC1 downstream Lysosomal Phosphoinositide signaling (MuscLY) – MuscLY
The lysosome is a signaling controller hub implicated in virtually every aspect of cellular physiology. Among myriad of assigned processes, a special attention was given to the master growth signaling
The Janus-faced Impact of caffeine in the developing and the ageing brain: role of synaptic remodeling – JANUS
Caffeine is the most consumed psychoactive substance in the world, including during pregnancy and breastfeeding. It has an impact on public health which depends on the period of exposure. Our consorti
Role of hepatocyte mitochondrial dysfunction in NAFLD onset and progression – IMHOTEP
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in industrialized countries, whose incidence is rapidly expanding worldwide. NAFLD is a frequent comorbidity of type
Gpr146 a novel target against lipid-related cardiovascular diseases – GENESIS
Despite major progress in the treatment against atherosclerotic cardiovascular disease (ASCVD), new therapeutic alternatives are needed for patients at very high ASCVD risk and/or with side effects up
Characterization of the mechanisms underlying glucocorticoids effects myositis (GC-MYOS) – GC-MYOS
Myositis are autoimmune diseases characterized by inflammation of skeletal muscle causing weakness and increased mortality. Glucocorticoids (GC) improve the disease through currently unknown mechanism
Exploring the roles of TMEM165-SPCA1 in Golgi Mn2+ and Ca2+ homeostasis, Golgi glycosylation regulation and protein secretion, application to TMEM165-CDG and HHD diseases – ENIGMncA
The ionic homeostasis of organelles in the secretory pathway is crucial to many fundamental cellular processes such as vesicular fusion events, protein secretion as well as the activity of many glycos
The neuropeptide 26RFa: a key player in the central regulation of glucose homeostasis, new therapeutic perspectives for Type 2 Diabetes? – DIABNET
Obesity and type 2 diabetes (T2DM) are strongly associated pathologies and are considered by the World Health Organization as an epidemic worldwide issue. Current treatments for T2DM, targeting the pe
Soluble CD146, novel target to prevent fibrosis during chronic kidney disease – CKD-fibrotarget
The interstitial fibrosis is a major health problem because it causes dysfunction of many organs and is responsible for a high degree of morbidity and mortality due to organ injury. The frequency of p
Investigating ineffective erytrhopoiesis in sickle cell disease – IRIS
Sickle cell disease (SCD) is a genetic recessive inherited disorder caused by a Glu-to-Val substitution in the ß globin protein resulting in abnormal hemoglobin (HbS) that polymerizes under hypoxia dr
Topologically induced non-reciprocal surface plasmons – Ti-P
The Ti-P project proposes to study the unique non-reciprocal plasmonic dispersion generated by the topological properties of the electronic band structure of Dirac Materials and of monolayer transitio