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Assessment of in vitro maturation of fresh and frozen prepubertal testicular tissue at the single cell level – sc-SpermInVitro
Testicular tissue freezing (TTF) is proposed to preserve the fertility of prepubertal boys before highly gonadotoxic cancer treatment. In vitro spermatogenesis is one of the potential approaches that
Role of Kupffer cells in hypercholesterolemia-driven cardiovascular risk – ROKHY
Cardiovascular disease (CVD) and its clinical manifestations, such as myocardial infarction and stroke, are the leading cause of mortality worldwide. Elevated plasma cholesterol concentrations are dir
complement and alarmin crosstalk in chronic inflammatory diseases – DYSALARM
Complement proteins have been considered for long to act only within this plasma-born enzymatic cascade, evolved to fight infections and to clean debris. Nevertheless, recent research, including from
Remodeling of bowel and bladder functions in spinal cord injury: revisiting the role of polyunsaturated fatty acid metabolites – BBSCI
Spinal cord injury (SCI) results in multi-organ impairment leading to increased risk of morbidity, mortality and disability. Symptoms resulting from spinal cord injury include pelvic (urological and d
Target phenotypic variation to enhance tuberculosis therapy – TREATABLE
TREATABLE project focuses on tuberculosis that remains a major global-health threat, also causing a quarter of the global antimicrobial resistance emergency, and is further exacerbated by the COVID-19
Role of Greb1l in mesoderm patterning and congenital heart defects – PATHPATT
GREB1L is a causative gene of a spectrum of human congenital defects, including renal agenesis. Yet the encoded protein is poorly characterised. Since the pathophysiology of congenital defects cannot
Interaction between PKA signalling and TRIM28 in ovarian maintenance and pathology – OvaryProtect
Gonadal sex fate in mammals is determined during embryonic development and must be actively maintained through adulthood. Therefore, gonadal sex-specific transcription factors are required to prevent
The impact of three-way crosstalk between intestinal epithelium, immunity and microbiota on bariatric surgery clinical outcomes – IMAT
The intestinal epithelium is a constantly renewing tissue that quickly adapts to its environment. The microbiota and immune cells, in contact with intestinal epithelial cells, can impact their functio
Pathophysiological role and plasticity of skin-projecting nociceptors in two major chronic skin disorders – NOMINATION
Atopic dermatitis (AD) and Psoriasis (Pso) are frequent chronic inflammatory skin conditions that affect around 7% and 3% of adults, respectively. These two diseases are driven by different (almost an
Muscle, Adipose and Pancreatic Islet Crosstalk in the Pathogenesis of Type 2 Diabetes – MYODIAB
Type 2 diabetes (T2D) is a life-threatening chronic disease associated with aging and a poor lifestyle. T2D is characterized by peripheral insulin resistance and impaired insulin secretion. The centra