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Gender Biases in Grant Allocation
Assessment of gender bias in grant peer review throughout the application and the evaluation phases
Long-term multi-dimensional neural probes for electrochemical detection of biomarkers in brain disorders
Neural prostheses offer promising perspectives to restore motor functions and communication capabilities in patients suffering from severe paralysis or neurodegenerative diseases. These approaches req
Sodium calcium dependent arrhythmias
The main objective of this project is to elucidate the mechanisms of life-threatening ventricular arrhythmias involved in sudden cardiac death (SCD), which accounts for about 15% of casualties worldwi
Multiscale estimation and Interface detection
Interface detection is a challenging question in image processing, and more generally in graph processing, leading to a large panel of applications going from geophysics research to societal studies. The common point to these applications is the willingness to have an interface detection at a fine scale, possibly with subpixel accuracy, in order to extract interpretable parameters (e.g. physical or societal), from high resolution data.
In silico models of drug transport to enhance personalized medicine
The IMOTEP (In silico MOdels of drug Transport to Enhance Personalized medicine) research project aims at building in silico molecular models of key pharmacological events of the patient response to m
Target Ion Source for Short-Lived Ion Production
The study of exotic nuclei is one of the main avenues of research with a high potential for discoveries worldwide. The TULIP project aims to enhance near-term nuclear physics research possibilities by creating unique radioactive ion beams (RIB) for ambitious subatomic experiments at the national flagship facility SPIRAL based at the Grand Accélérateur National d’Ions Lourds (GANIL) in Caen.
Regulation of cell-to-cell communication - the role of nanodomain-bound phosphoprotein REMORIN
Cell-to-cell communication is mediated in plants by plasmodesmata PD, plasma membrane pores between cells. How plasma membrane (PM) of PD is involved in regulated is mostly unknown. The understanding
Drug and target discovery for rare retinal dystrophies using patient-derived cellular models
Inherited retinal dystrophies (IRD) -including Retinitis Pigmentosa (RP) - that cause definitive loss of photoreceptors (PRs), typically result in permanent visual impairment. This study proposes to use patient-derived iPSCs to create advanced cell-based models mimicking photoreceptor degenerative profile observed in RP for drug and target discovery.
An antimicrobial origin of organelle targeting peptides
The vast majority of the proteome of bioenergetic organelles (chloroplasts and mitochondria) is imported into the organelle from the cytosol. This import is based on targeting peptides (oTP) located at the N-terminus of imported proteins, allowing their translocation through the envelope of organelles. The origin of these organelle targeting sequences and of the import machine that assist their translocation remains enigmatic.
Control of vesicular flows by golgins
The golgine GMAP-210 recognizes vesicles crossing the Golgi apparatus on the basis of their high curvature and lipid unsaturation level. Do other Golgines recognize other physicochemical properties of membranes? Does the role of GMAP-210 in immunological synapse formation also involve recognition of highly unsaturated membranes?
