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Role of phenology in species distribution and their management in a changing climate
Climate change impacts plants and animals in various ways, including poleward shifts of their geographical distribution and changes in their phenology (i.e., date of occurrence of life-stages). Our ob
ARCHI-SEC: Micro-Architectural Security
Security Analysis at Micro-Architectural level
Sensory, Motor and Cognitive plasticity in adults
Neuroplasticity, the capability of the brain to change its function and structure according to environmental pressures, is maximal during development and decreases with age at a different rate for dif
Hydrogen driven enantioselective assembly lines
The quest for new eco-compatible enantioselective paths requires the orthogonal catalytic activation of multiple building blocks. The solution to this challenge calls for the design of innovative mult
Glycan-dependent mechanical activation of the ß2-adrenergic receptor: a new pathophysiological paradigm
The present project will investigate several breakthroughs emerging from a previous study, in which we deciphered protein-protein interactions and signalling pathways activated by a bacterial pathogen
The Nuclear Pore Complex as a molecular hub to regulate replication fork repair pathways
Replication stress impacts fork progression and leads to chromosomal instability with profound impact on development, tissue homeostasis, neurological functions and aging. Although most signalling and
Development of a Mathematical Model of Signal Transduction and Adaptation in Mammalian Cone Photoreceptors
Development of a Mathematical Model of Signal Transduction and Adaptation in Mammalian Cone Photoreceptors The eyes of most vertebrates possess two kinds of photoreceptors: rods for dim-light visi
Fundamental, genetic and clinical aspects of male infertility due to severe sperm flagellar abnormalities
Although multifactorial, male infertility has a strong genetic basis, which has so far not been extensively studied. Previous work permitted to characterize and publish causative mutations in 9 genes. Here, the same consortium will leverage the previously acquired expertise and tools to further investigate the molecular basis of flagellogenesis and to translate this knowledge into actionable information and strategies to improve diagnosis and care of infertile patients.
Dislocations and Resistances. Persecutions and Genocidal Violences of Roma, Sinti and Travellers in Western Europe, 1940-1946.
This project studies, following a comparative and transversal approach, the persecutions against the Roma and Sinti, designated as “Gypsies”, “Zigeuner”, “Zingari” or “Nomads” in the geographical arc including the Netherlands, Belgium, France, Italy and Occupied Slovenia. The cross-analysis of the stages and mechanisms of a persecution includes a study of the trajectories at the level of individuals and collectives, based on a survey that is both historical and ethnographic.
Structure and molecular function of the pseudopilus in type 2 protein secretion pathway
Synergy_T2SS aims to decipher the structure and function or the pseudopilus - the dynamic motor of type II secretion system, and that in three model bacteria.The current models of the secretion mechanism - «piston« and «archimedes' screw« predict different pseudopilus dynamics and interactions with the secreted substrates. We aim to test these prediction using integrative approaches, and to propose a unified and experimentally validated model of type II secretion mechanism.
