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Advanced drying theory of capillary porous media from high-performance-computing pore network simulations
Improvement of drying theory of porous media from simulations on pore network. Consideration of the local non-equilibrium, the distinction between liquid percolating and non-percolating phases, coupling with external transfers.
Rare-earth-based alloys for hard magnetic applications: Temperature and pressure dependent phase stabilities
Hard-magnetic materials play a central role in current European efforts to develop sustainable energy concepts that allow climate protection. The functionality of most devices that contain electric en
Molecular Mechanisms Underlying Meiotic Cohesin Removal
In mitosis the correct segregation of the genetic material depends on the timely removal of a ring-shaped, DNA-embracing protein complex, named Cohesin. While phosphorylations in mitotic prophase remo
Early detection and prevention of cardiac dysfunction and heart failure induced by cancer chemotherapeutics
Cardiac dysfunction leading to heart failure can result from anticancer drug-induced cardiotoxicity. It is the second cause of morbidity and mortality among cancer survivors, a group that is growing
Communication between cardiomyocytes and innate immune cells in failing hearts
Ischemic heart Failure (IHF) is a leading cause of hospitalization and mortality in Europe. This unmet challenge asks for a better understanding of the mechanisms causing myocardial tissue damage and
Metabolic Therapy for Managing Diastolic Heart Failure
Heart failure with preserved ejection fraction (HFpEF) is the most rapidly increasing form of heart failure in the Western world. Despite high public-health importance, no treatment strategy has yet b
Novel RNA based therapies for treatment-resistant forms of severe cardiomyopathy caused by LMNA mutations
Standard treatment for heart failure (HF) most often fails to halt disease progression in patients who suffer from a mutation in the lamin A/C gene (LMNA). We aim to develop a molecular therapy for t
LIPCAR, a prognostic marker of heart failure with reduced ejection fraction
The objective of this proposal is the development of the long noncoding RNA (lncRNA) LIPCAR as a new diagnostic and prognostic marker for heart failure (HF) patients. Together Partner 1 (France) and P
