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Dynamics of DNA Repair within Chromatin and Transcription – DyReCT
Genome integrity is constantly threatened by a variety of toxic agents inducing lesions on the DNA molecule. Cells have set up systems to repair these lesions and restore the correct DNA sequence. Amo
Targeting the propagation of pathogenic protein assemblies in neurodegenerative disease – Neutargets
Emerging results suggest that the trigger of a variety of neurodegenerative diseases is the formation of pathogenic protein aggregates (“seeds”), which self-propagate in a prion-like manner. Current
A Longitudinal Analysis of Effects of Early Life Exposure to Phenols on Health in Humans – SHALCOH
Etude de l'effet de l'exposition aux phénols, des perturbateurs endocriniens peu persistants dans l'organisme, sur la croissance du foetus et la santé respiratoire du nouveau-né dans la cohorte couple-enfants iséroise Sépages
Integrative analysis of the biology of plasma cells in health and disease – AUTO-PLASMO
Plasma cells are essential for the development of an efficient and long-lasting protection against infections but they are also involved in the development of several autoimmune diseases. <br />This project main objective is to improve our knowledge of plasma cell biology, from their generation in the secondary lymphoid organs to their long-term maintenance in survival niches, and by doing so to identify new ways to target and regulate this cell subset.
Capillary flows of suspensions – POLYSHAPE
Polyphasic liquids (suspensions, emulsions, wetted foams) are ubiquitous in nature and industry (soils, pulps, pastes…). As for conventional liquids, there is an increasing need to optimize capillary
Common RNA-dependent pathways for motor-neuron degeneration in spinocerebellar muscular atrophy and amyotrophic lateral sclerosis – Fly-smals
The pathogenic mechanisms underlying motor neuron diseases such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) remain elusive. Strikingly, recent lines of evidence have sugge