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New generation of machine-learning based Models for Aerodynamics Computations – NEWMAC
In this project, we study new machine-learning methodologies to improve statistical turbulence models for aeronautical applications. In aerodynamics, currently used turbulence models in industry are b
PREdictive biomarkers in DYsTonia: defining the paradigm of monogenic dystonia to implement the diagnosis and prognosis of undiagnosed forms – PreDYT
The three main objectives (Os) of this project are, O1) to increase the diagnostic yield in dystonias, by detecting previously unrecognized etiological gene variants or by identifying less penetrant d
Development of diagnostic solutions for neurodevelopmental disorders caused by ubiquitin-proteasome system dysfunction – UPS-NDDiag
Neurodevelopmental disorders (NDDs) represent a heterogeneous group of conditions that persist throughout life, and affect more than 3% of individuals worldwide. NDD has a major impact on the affected
Central banking in hard times: Knowledge, legitimacy, and politics – KnowLegPo
Central banking is experiencing a severe crisis of both policy knowledge and political legitimacy. Since the global financial crisis of 2008, central banks – and the broader macro-financial order of w
Tax expenditures and the fiscal contract – TEFISCON
The project aims at shedding light on a topic that has not been widely researched so far: How does the use of tax expenditures in low- and middle-income countries impact on the fiscal contract? The n
Mechanisms of ribosome inhibition by context-dependent antibiotics – RibioTiX
The bacterial ribosome is a major antibiotic target. Although drugs that target the ribosome have largely been regarded as general inhibitors of translation that prevent the synthesis of all proteins
Deciphering the mechanisms of Carbapenem resistance propagation by studying conjugative Plasmid transfer – DeCa-P
In recent years, the global emergence of multi-drug resistant (MDR) bacteria has become a major public health problem and a priority for microbiology research. Resistance determinant are mainly carrie
Mass Spectrometry profiling of Bacteria with IR-desorption ionization on chemically functionalized porous silicon surfaces coupled to electrospray. Towards an early detection of sepsis. – MOONSTONE
Sepsis, blood bacteremic infection, is one of the first mortality cause in hospitalized patients. Survival chance decline by 7% each hour, while diagnostic required 5 days. There is an urgent need for
Optical imaging as a diagnostic tool for monitoring brain function in X-linked rare disorders: from preclinical models to patients – IMAGINER
Fragile X syndrome (FXS) and Creatine Transporter Deficiency (CTD) are the two most common causes of X-linked intellectual disability. Despite their etiological heterogeneity, FXS and CTD share common
Optimization of the diagnostic approach for inborn errors of immunity leading to hyper-inflammation – ODINO
Inborn errors of immunity (IEI) are a large group of genetic conditions that result in an alteration of the normal function of the immune response. Beside the classical primary immunodeficiencies (PID