Inhibition of platelet Protease Nexin-1 as a promising anti-bleeding strategy in haemophilia – ISPAHAN
Haemophilia A and B are inherited X-linked coagulopathies characterized by a lack of coagulation Factor VIII (FVIII) and factor IX (FIX) respectively. Haemophilia A affects about 1 in 5 000 and Haemop
Rethinking Land-Ocean Connectivity - An Integrated Approach to Understanding the Effects of Groundwater on Coastal Ecosystems – medLOC
The coastal zone hosts some of the most dynamic, diverse and productive ecosystems on Earth. These ecosystems experience significant pressure from human activities, and respond drastically to direct and indirect human disturbance and to climatic-hydrologic variability. The ecological ‘footprint’ of groundwater on hydrology, productivity and functioning of coastal ecosystems along the world’s shores is far less well understood, and remains virtually un-studied along most of the world’s shores.
Rifting of continental lithosphere is a fundamental process that controls the evolution of continents and the birth of ocean basins. Despite the fundamental place of rifts in our planet's geology and their economic importance, there remains first-order questions: What are the key parameters that govern successful versus failed rifting? To what extent is rifting due to the anomalous structure below, such as a mantle plume, or a passive response to far field plate-tectonic forces?
The aim of the MEUH project is to achieve the direct and selective oxidation of methane to methanol using catalysts confined in a supramolecular structure. This major challenge deals with crucial ener
One of the unsolved challenges of synthetic and systems biology is bottom-up prediction of gene expression from molecular interactions of regulatory molecules with the genome. Current high-throughput
BiPhoProc aims to demonstrate a highly innovative self-consistent bio-inspired computer, which hardware architecture is based on a hybrid digital (FPGA) and optoelectronic systems. The computing effic
Mechanistic and single-cell dissection of repressive 3D chromatin organization at facultative heterochromatin domains – Heterochromatin_In_3D
Mechanistic and single-cell dissection of repressive 3D chromatin organization at facultative heterochromatin domains
Adolescence is characterized by changes in skills, motivations, and social landscape, as well as in brain structure and function. But how these domains of plasticity are interrelated is unknown. Recen