The adult brain keeps the potential to generate new neurons throughout life. In this project we want to understand how this adult neurogenesis is regulated.
A fundamental work is dedicated to the global and local structural order characterization of the different phases present in the industrial catalyst. We would like to elucidate the probable dynamic effects which may be present in different phases constitutive of the active catalyst and influence the reactivity of the material in the operating conditions. For that purpose, a combination of multiscale X-ray scattering experiments and solid state NMR analysis in Operando conditions is developed.
Mn+1AXn phase is the generic formula for a family of layered ternary carbides and nitrides where M is an early transition element, A is an element of group III-A or IV-A and X is either C or N. The st
The METIS project is dedicated to the study of the biomechanics of connective tissues. Soft connective tissues such as skin, tendon or cornea are made of more than 90% of extracellular matrix proteins
The work conducted during this project relied on the analysis of measurements from the MESSENGER probe (NASA), in orbit between 2011 and 2015. We were able to 1/ describe Mercury's magnetic environment (from the dynamo field to interactions with the solar wind), and 2/ design and test different tools to extrapolate models, add additional constraints and parameters, and better prepare the observations of the BepiColombo mission.
In the areas of safety, health and environment, the detection of chemical compounds, VOCs and toxic gases, is a major societal concern. The explosion in recent years in the telecommunications market h
NeuroInflammation and Cognitive decline in Alzheimer’s Disease : a pilot study of PET imaging of the translocator proteine ligands (TSPO) with [18 F] DPA-714 (NICAD) – NICAD
Neuroinflammation and cognitive décline in Alzheimer's Disease (AD)<br />Neuroinflammation is involved in AD, characterized by microglial activation. Microglial activation may be evaluated using PET [18F]DPA-714. Our hypothesis is that pronounced microglial activation might be more likely to be associated with rapid cognitive decline in AD patients.
Three dimensional microscopy of ocular tissues using full-field OCT: application to transplantation of tissues and cells for eye diseases – MicroEye
The MicroEye project aims to transfer full-field OCT to ophthalmology practice. This breakthrough technology enables nondestructive histology, and is expected to improve clinical processes including graft and bioengineered tissue evaluation, and analysis of surgically extracted tissues.<br />
Therapeutic potential of AMPK activators for correction of mitochondrial fatty acid ß-oxidation disorders. – THERABETAOX
Inborn enzyme defects of fatty acid ß-oxidation (FAO) form a group of genetic disorders associated to life-threatening pediatric presentations, or to milder phenotypes with later onset and severity. A
Destruction of pancreatic beta-cells leads to absolute insulin deficiency in type 1 diabetes and concerns some 15 to 30 million patients.Transplantation represents one therapeutic choice in patients with serious progressive complications of diabetes. Currently no method has been established to test and evaluate the quality of the islets and their preparation within the short time span (few hours) prior to their transplantation.