Retinitis Pigmentosa diagnosis and therapy: retinal remodeling and optogenetic reactivation of degenerated retina – OPTOREMODE
Retinitis pigmentosa (RP) is a hereditary rare disease of the retina leading to incurable blindness. When most photoreceptors degenerate and lost their ability to respond to light, a substantial quant
EUropean PLAtelet NEtwork for studying physiopathology of two inherited thrombocytopenias, THC2 and MYH9-RD, characterized by genetic alterations of RUNX1-target genes – EUPLANE
The aim of this project is to identify the pathogenetic mechanisms of two inherited thrombocytopenias both described for the first time by partner 1. The first, MYH9-related disease, is characterized
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multifocal motor neuropathy (MMN) are rare neuromuscular diseases lacking diagnostic biomarkers. During the last decade, our teams
Research on early language acquisition has shown that prosodic information is one of the earliest cues infants use to bootstrap into the acquisition of lexical and syntactic properties of the target l
ACTH-independent Cushing’s syndrome (AICS) is a very rare condition ( < 0.6/million/yr) due to primary adrenal cortex dysfunction that causes chronic cortisol excess leading to significant morbidity a
Etiological and pathophysiological contributions of impulsivity trait and anhedonia to impulse control disorders in Parkinson's disease – IMAPARK
Study of the role of some personnality traits (impulsivity, depression, anhedonia) and neurobiological dysfunctions in the development of impulse control disorders in parkinsonian patients.
With the recent discovery of biased ligands for GPCRs, new possibilities are available for the development of more specific therapeutics acting on GPCRs. It is then necessary to precisely study signal transduction pathways of any GPCR in its native environment. Our main goal is to develop such assays.
Autism, complex and heterogeneous neurodevelopmental disorder, is characterized by social behavioral impairments and hippocampal fragility. While studies involving mutant mice have begun to reproduce both social behavioral impairments and hippocampal synaptic dysfunctioning, defining the exact role played by the hippocampal synaptic plasticity and integrity in social behaviors, and its functional alteration in autism, will greatly enhance our understanding of the pathophysiology of autism.
Background<br />In France, mental disorders represent a significant epidemiological and economic burden that is expected to increase dramatically in upcoming years. Equity, efficiency and quality of care are therefore of key importance in psychiatry but they can be challenged by unwarranted practice variations. Evidence-based policies are therefore needed to reduce those variations.<br />
This projet relies on the formal study of tasks that can be efficiently performed on text documents (structured or not) when accessed as streams.