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Targeting dendritic over-inhibition to alleviate cognitive deficits in Down syndrome. – DendriDOWN
Down syndrome (DS), caused by trisomy of human chromosome 21, is characterized by cognitive deficits and over-inhibition of cortical circuits. We showed previously that acute treatment of DS mice with
Are megakaryocyte podosomes relevant targets in thrombocytopenia? – MegaPod
Background. Thrombocytopenia is defined as an abnormally low blood platelet count, exposing patients at high risks of hemorrhages. It is a common clinical problem in chemotherapy-treated cancer patien
Defining the role of glucocorticoids signaling in aging and age-related metabolic disorders – GLUCAge
Aging is a progressive physiological decline that predisposes individuals to age-related pathologies such as cardiometabolic diseases, leading causes of death in Europe. Loss of adaptation to various
Therapeutic role of CD44 in alcoholic liver diseases: from bone marrow myelopoiesis to liver inflammation – MYELASH
Alcoholic liver diseases (ALD) are the most prevalent causes of advanced liver disease in Europe and major drivers of liver-related morbidity and mortality. Chronic inflammation (ASH) is the progressi
Control of energy metabolism by thyroid hormone in the hypothalamus – HYPOTHYRO
A better understanding of the brain mechanisms that control food intake and energy metabolism would help to face the worldwide obesity epidemic. Thyroid hormone is a key regulator of the hypothalamus
Alternative telomere protection – EARLYTEL
Mammalian telomeres are composed of a tandem array of specific DNA motifs, to which a dedicated set of factors named shelterin proteins specifically bind. Shelterin proteins regulate telomere replica
Role of long non-coding RNA in domain-wide regulation and gene repression at imprinted gene loci – IMP-domain
Genomic imprinting is an epigenetic phenomenon in mammals, where mono-allelic expression of genes during development depends strictly on the parental origin of the gene. Imprinted genes play key role
Chromatin remodeler CHD1L in neurogenesis and in 1q21.1 Copy Number Variant-associated neurodevelopmental phenotypes – CHROMATISM
Recent technological advances have accelerated the discovery of copy number variants, (CNVs; deletion or duplication of DNA fragments larger than 1 kilobase), genomic lesions that contribute significa
EpiGenOmics/genomic/metabolic interplay in pathomechanisms of iNborn Errors of methionine metabolism. – EpiGONE
The cblC type of rare disease of vitamin B12 metabolism due to mutations in the MMACHC gene is a severe and sometimes fatal disease with metabolic decompensation, megaloblastic anemia, retinopathy, ne
Cholesterol trafficking in cardiovascular diseases – TRAFIC
Intracellular cholesterol trafficking is essential for the maintenance of vascular integrity. However, the mechanisms by which cholesterol is transported into the cell are poorly understood. Recently,
