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Novel Predictive Models for Cancer Pharmacogenomics to Improve Molecularly Targeted Therapy – ModellingCancerOmics
Drug combinations are a well-established form of cancer treatment1. Administering more than one drug can provide many benefits: higher efficacy, lower toxicity and at least delayed onset of acquired drug resistance2–4. Serendipitous discovery in the clinic has been a traditional source of effective drug combinations5,6. Yet systematic large-scale efforts to identify them have only recently been pursued.
FoRmal mEthods for the Design of Distributed Algorithms – FREDDA
Distributed algorithms are nowadays omnipresent in most systems and applications. It is of utmost importance to develop algorithmic solutions that are both robust and flexible, to be used in large sca
L functions in families: analysis, interactions, effectiveness – FLAIR
L-functions are ubiquitous objects in Number Theory and Arithmetic Geometry. They are analytic, algebraic, or combinatorial in nature. Recently attempts have been made to formalize the notion of ``goo
Interplay between BK polyomavirus genetic evolution and humoral response: Toward new biomarkers of severe infection and antibody based immunotherapy – BKNAB
BK polyomavirus (BKPyV)-associated nephropathy (PVAN) remains an important cause of kidney transplant (KTx) dysfunction. There are few treatment options available for KTx recipients with sustained hig
LATE ONSET HEARING IMPAIRMENT: FROM DISEASE MECHANISMS TO THERAPY – HearInNoise
Hearing impairment, the most frequent sensory deficit, causes communication difficulties, often associated with social isolation, depression and reduced physical and cognitive function, with a dramati
5-HT6 receptor-operated mTOR signaling as a target for disease modifiers to prevent onset of cognitive deficits in schizophrenia. – StopSero6TOR
Schizophrenia is a devastating mental disorder of neurodevelopmental origin, which affects ~1% of the population worldwide and represents a major socio-economic burden. It is characterized by a broad
Resetting self-tolerance in autoimmune diabetes by pro-resolving mediators derived from apoptotic cell efferocytosis – DIAPOP
Type 1 diabetes (T1D) is a chronic autoimmune disease mostly affecting children and young adults and resulting from the selective destruction of insulin-secreting pancreatic ß-cells by autoreactive T
Measuring Acidification in the Arctic Ocean – MACAO
Ocean acidification is a direct consequence of the CO2 increase and a threat for marine ecosystems.
Effects of convection and cirrus clouds on the Tropical Tropopause Layer over the Indian Ocean – CONCIRTO
CONCIRTO is a 62-month young researcher project funded by the National Research Agency. It aims to study the impact of deep convection and cirrus on the water vapor balance in the tropical UTLS of the southern hemisphere.
Chalcitrine and sclerocitrine: how nature can produce chemical diversity? – X-comic
Nature is able to assemble simple chemical building blocks and increment structural complexity to produce highly refined natural products. In this context, chalcitrin and sclerocitrin, two pigments displaying highly complex molecular structures isolated from common mushroom represent ambitious synthetic targets.