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Bottom-up assembly of Functionalized Nanohelices: a further step towards flexible devices – NANOHELIFLEX
Bottom-up assembly of functionalized nano-helices: a further step towards flexible devices
New titanium alloys with a combination of high strength, strain hardening and high ductility, induced by TRIP and TWIP effects – TITWIP
The TITWIP project is focused on the development of a new family of titanium-based materials capable of transforming under the effect of deformation, either by phase transformation or by mechanical twinning. This feature gives them a high mechanical strength combined with a strong strain-hardening and a high ductility.
Tooth diseases: Porphyromonas active secretion of toxin effectors – TOOTHPASTE
Periodontitis and gum diseases are considered as major public health concerns as roughly 36% of the world population (20% in industrialized countries) suffer of serious tooth tissue damages and tooth
Pseudomonas aeruginosa–induced hemorrhagic pneumonia: deciphering novel virulence strategies – HemoPseudo
Pseudomonas aeruginosa is an important nosocomial pathogen, associated with high mortality rates, in part attributable to high level intrinsic resistance to antibiotics. Our group recently characterized highly virulent P. aeruginosa clinical strains and a novel toxin, named Exolysin (ExlA) for which the virulence mechanisms are still unknown.
Analysis of the GABAergic synapse using structural and genetic strategies in the C. elegans model organism. – GABAREL
GABA is the primary inhibitory neurotransmitter in the nervous system. Changes in GABAergic neurotransmission contribute to the etiology of prominent neurological and mental disorders including epilep
A new approach to inhibit ErbB2 signaling and design new drug candidates: targeting the EGF domains of its membrane partner, the MUC4 mucin – DRUG_MUC4
The general goal of the DRUG_MUC4 project is to study the structure-function relationship of the MUC4-ErbB2 complex and propose new small inhibiting therapeutic molecules targeting MUC4-EGF domains.<br />The aberrant overexpression of the transmembrane MUC4 mucin, its partnership with ErbB2 and the negative consequences of the activity of MUC4-ErbB2 complex on epithelial homeostasis, has allowed identification of MUC4 as a highly attractive therapeutic target (Kufe, 2009).
Sequence and structure of the packaging signals of the influenza A virus genome – PSiFlu
Sequence and structure of the packaging signals of the influenza A virus genome. The genome of influenza A viruses consists of 8 vRNAs that associate to a polymerase complex and multiple copies of nucleoprotein. The 8 resulting ribonucleoproteins are selectively incorporated in the viral particles thanks to the presence of packaging signals on each vRNA.