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Role of the microbiome in the macrophage response to Mycobacterium tuberculosis: A research program to integrate microbiota, metabolism and immunity – MMI-TB
BACKGROUND. Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB) in humans, still claims around 1.5 million lives yearly. In fact, TB is among the three most deadly diseases du
Molecular and cellular caracterization of novel bacterial nucleomodulins – NucPath
The goal of NucPath is to characterize Brucella nucleomodulins by defining how they alter nuclear dynamics and affect host gene expression, allowing Brucella to subvert host responses and establish an intracellular niche suitable for replication.
Implication of prokaryotic Rab-GTPases in pathogenesis and disease – ProRab
Pathogens that are able to enter and multiply within human cells are responsible for a large disease burden worldwide. Legionella pneumophila and Legionella longbeachae the causative agents of a sever
Self-mediated shaping of naïve CD4 T cell effector fate – Self-shaped-CD4_TN
Our recent works identify a link between the tonic TCR signaling that CD4 TN cells receive in the steady state and their fate in the effector phase. We have demonstrated that TCR/self-MHC interactions not only increase quantitatively but also shape qualitatively the response of CD4 TN cells to their cognate antigens in the effector phase. Indeed, we have demonstrated that CD4 TN cells with the highest avidity for self-MHC have a biased commitment toward the iTreg cell lineage.
Human infection with zoonotic simian foamy retroviruses: role of virological and immunological factors in restricting viral emergence – REEMFOAMY
The public health relevance of retroviruses of zoonotic origin is illustrated by the human immunodeficiency virus (HIV) epidemic, the worldwide distribution of human T-lymphotropic viruses (HTLVs), an
Interactions of Listeria monocytogenes with the intestinal epithelium – OrganoList
The intestinal epithelium constitutes a tight barrier for enteric microorganisms, which only few enteroinvasive pathogens, including Listeria monocytogenes (Lm) have the ability to cross. We have show
Single Cell Analysis of Plasmacytoid dendritic cells to understand their heterogeneity for INterferon production – SCAPIN
Different cell types perform distinct functions. Heterogeneity also exist in each cell type but its biological meaning remains puzzling. Intra-type heterogeneity at ground state might allow plastic responses to stimuli. We will test this hypothesis by determining whether, and how, ground state intra-type heterogeneity is related to functional heterogeneity upon activation. We will also exploit intra-type heterogeneity to better understand how cellular functions are molecularly regulated.
Cytoskeleton remodeling by storage endosomes – molecular mechanisms and impact on the immune response – CytoEndoStor
Slow recycling storage endosomes (SRSE) are a particular endosomal population that is described by the aminopeptidase IRAP, a protein with dual function.
Innate lymphoid cells and immunological memory – ILC3_MEMORY
Within the lymphoid compartment, B and T cells that deliver adaptive immunity are well recognized as essential players in the clearance of pathogens and development of immunological memory. In contras
Lighting up fleas to understand the complex transmission mechanisms of Yersinia pestis – LUCY
Better decipher the transmission mechanisms of plague through new approaches in order to eradicate it.