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Cadmium and Deoxynivalenol in durum wheat grains: understanding the co-contamination and the associated toxicity.
Cadmium (Cd) and mycotoxins are among the most worrying contaminants that threaten the safety of food products derived from cereal kernels. Indeed, as recently supported by the last French total diet
Cadmium and Diabetes
The project Cadmidia aims at understanding the relationship between low level exposure to the widespread contaminant, cadmium, and dysfunction of pancreatic beta cells, which is a strongly contributin
Caged Peptides to Block Endocytosis
Endocytosis, the internalisation of vesicles from the plasma membrane of cells, is a fundamental process of eukaryotic cell biology. To study their molecular mechanisms and role in cell biology, we propose to develop molecules to visualize and block endocytosis selectively in live cells.
Cajal-Retzius neurons: from migration in the cerebral cortex to the construction of functional and dysfunctional neural circuits
The neocortex controls sensory perception, motor behaviors and cognitive functions. These functions rely on a complex architecture of neural networks that begins to be established during embryonic dev
Calcium carbonate Multifunctional Particles elaborated in supercritical CO2 medium. Application to controlled release of therapeutic proteins for tissue engineering
Osteoporosis and degenerative arthropathies are in constant increase due to population ageing. The important sport practicing in modern societies leads also to articular traumatism with high prevalenc
Calcium dependent mechanisms of activation of pancreatic stellate cells
Recent progress in modern medicine has shown that numerous pathologies are actually channelopathies (i.e. alterations in an ion channel’s structure and function). The development of cancers also invol
Calcium phosphate bioceramics with controlled porosity as local drug delivery systems
Inorganic materials, such as calcium phosphate ceramics, widely used as bone substitutes, are also good candidates as drug carriers. The drug substances, included in the micropores of the ceramics, ar
Calcium pyrophosphate crystal formation and osteoarthritis: in vitro and in vivo studies
Osteoarthritis (OA) is the most common form of chronic rheumatic diseases (37 millions of European people) and current treatments are chiefly designed to relieve symptoms until joint replacement becomes necessary. The presence of calcium-containing microcrystals (hydrated calcium pyrophosphates (CPP) and calcium phosphates) in the joint has been identified as an aggravating factor but current treatments are solely symptomatic and are not able to dissolve/prevent the formation of CPP crystals.
