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SPInodal DEcomposition Reaction in MArteNsitic Fe-X-C alloys – SPIDERMAN
SPInodal DEcomposition Reaction in MArteNsitic Fe-X-C alloys<br /><br />Atomic scale investigation of the low temperature tempering processes (T<150°C) of virgin ferrous martensites
Bisubstrate and prodrug approaches for the rational design of new DXR nhibitors: Novel antimicrobial and antitubercular drugs – ANTITUB
Today, almost all important microbial infections throughout the world, such as tuberculosis, malaria, nosocomial diseases, are becoming resistant to antibiotics. Antimicrobial multi-drug resistance has been called one of the world's most pressing public health problems. It is therefore urgent to find innovative targets for new antimicrobial drugs.
Synthesis of aminoacyl-tRNA analogues to explore non-ribosomal peptide synthesis in bacteria – MimictRNA
Our project will provide for the first time insight into the catalytic mechanism of Fem transferases, structural data on tRNA recognition by these enzymes, and insight into the mechanisms that control the flux of aminoacyl-tRNAs into protein and peptidoglycan synthesis. The project should bring all the tools required for the design of drugable inhibitors of Fem transferases and other tRNA- dependent bacterial targets, such as the aminoacyl-phosphatidylglycerol synthetases.<br />
Turbulence and dynamo in planetary cores – TuDy
Numerical dynamo simulations have brought a lot about the role of rotation in the generation of magnetic fields in<br />planets and stars.<br />Nevertheless, the organization of small-scale fluctuations remains out of reach of these simulations. If we try<br />to build plausible scenarios of the cascade of kinetic and magnetic energies from the measured large-scales<br />down, we see that classical ideas on magnetohydrodynamic turbulence would yield unrealistic estimates of dissipation in the Earth’s core.
Investigating MAGnetism of INtErmediate-mass and massive stars – IMAGINE
IMAGINE investigates the magnetism of massive and intermediate-mass stars to better understand its origin and its impact on stellar evolution.
MOdeling JOvian planet growth – MOJO
How giant planets form is one of the major open issues in planetary science. This limits our understanding of the origin of planetary system architectures and the conditions needed for the formation of habitable terrestrial planets. In this project we will test new ideas on the growth of giant planet cores and planetary embryos by pebble accretion, the interplay between growth and migration, as well as gas accretion by giant planets
Dynamical magneto-electric effects : probe and theory of hybride excitations – DYMAGE
Dynamical magnetoelectric effects: probe and theory of hybride excitations
From sequences to structure: statistical-physics methods to infer co-evolutionary constraints in proteins and RNAs – COEVSTAT
In the course of evolution, structure and function of biomolecules, e.g. proteins, RNA, are remarkably conserved, whereas amino-acid/nucleotide sequences vary strongly between homologous, i.e. evoluti
On the Regulation of Carbonic anhydrase Activity and the COS and CO18O fluxes in terrestrial ecosystems – ORCA
Quantifying CO2 budgets and predicting the sensitivity of terrestrial ecosystems to climate change requires the ability to estimate fluxes of photosynthesis and respiration at large scale (region, globe). Currently, these estimations mainly results from models with large uncertainties. We propose here a multi-tracer approach allowing us to constrain estimations of photosynthesis and respiration at large scale and better represent these processes in vegetation models.
Development of a Single-gap-photoneutralizer injector with energy recovery for the future fusion reactors (ITER, DEMO) – SiPhoRE
The project aims at demonstrating the feasibility of a nearly complete neutralization of a beam of H- or D- by photodetachment. This is to be applied to the production of energetic neutral beams, suit