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Pharmacological exploration of the role of Acid-Sensing Ion Channels in pain – PharmASIC
To provide a better understanding of the mechanisms of pain by exploring with innovative pharmacological tools the role of Acid-Sensing Ion channels (ASICs) in these processes, and to provide at the same time leads in the development of new analgesics.
Decoding hypothalamic nutrient sensing and food intake regulation via mTORC1, melanocortin and endocannabinoid interactions. – NeuroNutriSens
In order to find new therapeutic targets for the treatment of obesity and metabolic disease, it is necessary to study the biological mechanisms that control food intake and body weight. The NeuroNutriSens project investigates the role of novel molecular mechanisms that, within the hypothalamus, play a role in the detection of the nutritional status and in the regulation of food intake.
Optogenetic control of the neuronal network responsible for paradoxical (REM) sleep atonia – OPTOREM
Paradoxical sleep (PS) is characterized by an atonia of the whole somatic musculature sporadically interrupted by muscle twitches. The identification of the mechanisms controlling the motor activity during PS is clinically relevant since an abnormal regulation of the muscle tone occurs in three of the major disabling sleep disorders, i.e. REM sleep behavior disorder (RBD), narcolepsy with cataplexy or obstructive sleep apnea (OSA).
Regulation of Immune Responses by Proteoglycan/Chemokine interactions: from structural to in vivo approaches – ChemImmun
Most chemokines bind not only their specific receptor, but also components of the extra-cellular matrix, becoming immobilized. This immobilization process drives cell motility (haptotaxis) and promotes synchronous cell-adhesion in spatially confined compartments.
High Density CVD/PVD Plasmas for SiNOCH coatings (focus on plasma/surface/interface for optical and electrical properties) – HDPlasm-A-SINOCH
Thin films based on oxides, nitrides or carbides, for optics, dielectric properties (SiO, a-SiCO:H) and passivation (a-SiN:H), are used in microelectronics (insulation of contacts) in the field of opt
Ultrafast high-BRightness Infrared laser sources at 2 µm – UBRIS2
UBRIS2 aims at developing innovative ways towards the realization of high-power ultrafast laser systems at the exotic wavelength of 2 µm. The project gathers researchers and engineers from XLIM, CORIA
Hydrogen plasma in INteraction with Diamond : EXTReme Ion Production and Low Erosion Desired – H INDEX TRIPLED
The present project is put into the context of the international projects ITER and DEMO aiming at managing nuclear fusion to produce energy. In tokamaks (nuclear fusion reactors), a hot plasma compos
Molecular Quantum Spintronics – MolQuSpin
A revolution in electronics is in view, with the contemporary evolution of three novel disciplines, spintronics, molecular electronics, and quantum computing. A fundamental link between these fields c
Thermally Optimized Nanoantennas for Nanometer-scale energy conversion – NATO
Focusing light on the nanoscale in order to create intense optical or thermal nanosources is probably the main challenge facing the nano-optics community, in order to power up future devices. Metallic
Functionalized Nanowires as Ultrasensitive Sensors – FOcUS
The goal of our project is to develop and disseminate ultrasensitive versatile force sensors based on nanowire or nanotube oscillators probed by optical means. The exploration of the nanoworld req