Search
From fragments to inhibitors of MabA (FabG1) a new challenge to treat tuberculosis
Innovative medicinal chemistry approach involving the design and synthesis of low molecular weight molecules, the use of high-throughput assays for measuring enzymatic and bactericidal activities of compounds and ADME profiling
Mechanical control of cell migration and proliferation by Adherens Junctions and the LINC complex
In multicellular organisms, tissue morphogenesis is thought to result from the combined influence of the genetic program and environmental cues on cell behaviors. As embryonic development proceeds, ce
INferring Anomalous Diffusions in LIving Cells from single particle tracking experiments
Single particle tracking techniques are remarkable and unique tools for studying structural, dynamical and functional properties of living cells. Le major challenge consists in statistical analysis and biophysical interpretation of the acquired random trajectories. The project aims at gathering physical, biological and statistical expertise to build a new protocol for reliable inference.
Metabolic engineering of a green microalga for production of medium-chain alkanes
One of the major issues faced by modern societies is energy. Producing energies from biomass poses as one of the most attractive solutions. Microalgae offer several advantages: its high biomass produc
Next steps in Synthetic Biology: towards the generalization of genome transplantation methods
SYNBIOMOLL aims at extending Synthetic Biology key technologies to Mollicutes species of interest. Because several bacterial genomes have already been cloned in yeast and the synthetic assembly of large DNA fragments is in current use, the major technological limitation is our ability to extend the genome transplantation technology to other microbial species. This project could therefore lead to a better comprehension of the biology of pathogenic bacteria and the development of new vaccines.
System matrix modelling for photon propagation in patient using transmission information and convolution of kernels on graphical processing unit
Single Photon Emission Computed Tomography (SPECT) is a medical imaging modality based on the administration of radiolabeled molecules (RM) to patient. The administrated RM should have the specificit
Role of c-di-GMP in the riboswitch and antisense RNA-mediated control of cellular processes associated with community behaviour in Clostridium difficile, a bacterium responsible for nosocomial infections
Our project will bring to light new aspects of RNA-based control of key steps during the infection cycle of an important human pathogen Clostridium difficile like biofilm formation and defenses against bacteriophages via CRISPR system.
Viral RNA enriched exosomes are mediators of the interferon response
Our project aims at defining this newly discovered aspect of the innate immune response triggered by cell-to-cell contacts between virally infected cells and cells specialized for the antiviral response. In particular, we determine the importance of the cell contacts, the carrier of the transmission, the viral and cellular determinants and the induction pathway.
Functional analysis of the autophagic pathway in Toxoplasma gondii
The autophagy (self-digesting process) machinery is very conserved from Man to unicellular eukaryotes. Toxoplasma is a eukaryotic pathogen in which almost nothing is known about the functions of this machinery. We have thus started deciphering the particular roles of autophagy-related proteins in this parasite.
Regulation of inflammasome activity by NLRP3 ubiquitination
Inflammation is a protective response against infections and tissue damages. Its deregulation contributes to diverse pathologies including septic shock, atherosclerosis, diabetes, Alzheimer's disease, and auto-inflammatory diseases.
