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Targeting the 2C protein of enteroviruses to develop broad-spectrum antivirals derived from Fluoxetine
Enteroviruses (EVs) are pathogens of increasing public health concern with recurrent emerging agents. Although many EVs are associated with mild clinical manifestations, they can lead to serious compl
Targeting the ?-lactamases’ expression with lipid oligonucleotides to fight against antibiotic resistance in enterobacteria
To fight against bacterial resistance to antibiotics, we propose to use chemically modified Lipid OligoNucleotides (LON) to restore, via base pairing to mRNA of a targeted gene, sensitivity to the ant
Targeting the Adapted colonic Microbiota for a better recovery after Intestinal Resection
Short Bowel Syndrome (SBS) results from an extensive intestinal resection and is the leading cause of intestinal failure. In addition to parenteral nutrition, an effective pharmacological treatment wi
Targeting the IL-20/IL-22 balance to restore pulmonary, intestinal and metabolic homeostasis after cigarette smoking and unhealthy diet
Cigarette smoking and unhealthy diet (SCUD) are major behavioral risk factors that contribute to the alarming rise in non-communicable inflammatory diseases. Cigarette smoking is often associated with
Targeting the IRE1 branch in steatohepatitis
The incidence of Non-alcoholic fatty liver disease (NAFLD) is constantly increasing, owing to the obesity epidemic. The first step in the course of NAFLD progression is hepatic steatosis. Steatosis ca
Targeting the LRRK2-PP2A complex in Parkinson’s disease
Neurodegenerative diseases represent a major public health issue that needs to be addressed. Among them, Parkinson's disease (PD) is considered as the most common motor pathology but for which no cura
Targeting the RAS-MAPK Signalling Pathway for treating movement disorders
Levodopa-induced dyskinesia (LID) represent a debilitating complication of levodopa therapy for Parkinson's disease (PD), which underlying neural mechanisms are far from clear although major advances
Targeting the Wnt/beta-catenin cell signalling pathway in liver primary cancers
Hepatocellular carcinoma (HCC) is one of the most common cancers in men and the third most common cause of cancer mortality, worldwide. Most chronic liver diseases from either viral (Hepatitis B and C
Targeting the chondrocyte-derived CXCL12/endothelial cell CXCR4 axis in osteoarthritis
Osteoarthritis (OA) affects around 40 million people in Europe. OA causes a heavy socioeconomic burden. There is currently no cure for OA. Also, the development of therapies that can prevent joint dam
Targeting the chromatin environment of the influenza virus transcriptase to interfere with the virus cycle
The objective of the present proposal is to determine how the transcriptase machinery of Influenza A virus (IAV) is targeted to chromatin, to explore the global impact of the virus on host chromatin s
