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A new generation of interacting resonators: non-Hermitian and time modulated coupling – WHEEL
Coupled resonances across many areas of science, e.g. physics and chemistry, serve as defining pillars of their fields. In recent years, fundamental studies and applications have experienced a large e
A new pathway for reducing liver lipotoxicity bridging non-alcoholic steatohepatitis and atherosclerosis in type 2 diabetes – DETOXING
Nonalcoholic fatty liver disease (NAFLD) is an increasing chronic liver pathology affecting around 25% of the general population in Western countries. NAFLD is a continuum of pathological states rangi
A novel 4D ex vivo human lymphoma model to assess CAR T and NK cell efficacy – 4D-CARLY
Adoptive transfer of T and natural killer (NK) cells expressing chimeric antigen receptors (CARs) has shown remarkable clinical efficacy against advanced B cell malignancies. However, many patients do
A novel druggable pathway of chronic kidney disease – STOP-CKD
Chronic kidney disease (CKD), a major socioeconomic worldwide public health burden, is characterized by a progressive decline in renal function to end stage renal disease that can occur irrespective o
A novel posttranslational control mechanism for EXOSC10/Rrp6 – EXOPROT
The conserved 3’-5’ exoribonuclease EXOSC10 (Rrp6 in yeast) is essential for early embryogenesis, development of the forebrain and red blood cells, gametogenesis and cancer cell division. Among the pr
A pharmacological therapy for HNF1B-deficiency – DrugHNF1B
HNF1B is a transcription factor whose mutations represent the most common genetic cause for “Congenital Abnormalities of the Kidney and the Urogenital Tract” (CAKUT). In addition, mutations in HNF1B
A portable SPRi device with high spatial resolution for the detection of pathogens – eSPRi
One of the lessons taught by the Covid-19 pandemic is the need for rapid, portable and low-cost systems for the detection of pathogen to stop their spreading. Currently, the existing methods are not s
A prospective analysis of the tensions between higher self-sufficiency and a healthier, more sustainable food system – SOUVNUTRI
How and to what extent the French food production system could ensure healthy and sustainable diets for its population while increasing its capability for self-sufficiency? From a political point of
A radical approach to new organic light-harvesting materials – RADPOLIMER
This project unites cutting-edge advances in spectroscopy, chemistry and simulation to engineer and directly visualise the electronic photodynamics of a new class of organic light harvesting materials
A rare case of monogenic KCC2-related autistic spectrum disorder: a new benchmark for the validation of causality and treatment screening. – AuDy
The proposed project is a collaborative effort of clinicians and neurobiologists aiming to understand the cellular and molecular mechanisms responsible for autism spectrum disorder (ASD) in a family o