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Biodiversity and Ecosystem Service Scenarios Network
The goal of the ScenNet project is to strengthen national and international ties between researchers working on scenarios of biodiversity and ecosystem services. The project involves researchers from
Impact of human drivers (fire, agriculture and grazing) on biodiversity in savannas
Savannas contain a significant part of the biodiversity worldwide, hosting many plant species but also a great variety of animals, including most of the world’s megafauna, which constitutes an important source of income for many African countries. This project will examine a simple set of change scenarios in human activities, in interaction with climate change when required, coupled with ecological dynamics.
Pottery production and consumption in Ptolemaic-Roman Egypt
CERAMEGYPT is a Franco-German research project coordinated by Jean-Yves EMPEREUR (CNRS, member of the Institut de France) and Michael HEINZELMANN (University of Cologne). The project began 1 January 2015 and has run for 48 months. It is the recipient of an ANR grant to the value of €389,996.
Fast Skeletal Troponin Activation for Restoring Muscle Strength in Mouse Models of Nemaline Myopathy: a Molecular, Cellular, Metabolic and Functional Assessment
Nemaline myopathy (NM) is a rare and fatal neuromuscular disorder with an estimated prevalence of 1 in 50.000 live births. The main clinical feature of NM is muscle weakness, which impairs swallowin
New treatments for auto-inflammatory diseases
Systemic juvenile idiopathic arthritis (sJIA) is a rare, multifactorial, autoinflammatory disease which is one of the gravest chronic diseases in childhood. In addition, sJIA is associated with a life
Cysteamine for the treatment of cystic fibrosis: a translational research project
The proposed approach focuses on a bottom-up, cost-effective strategy of drug discovery in CF in which drugs, already approved for other human diseases or natural compounds with well known safety pr
Common Pathogenic Pathways and Therapeutics for SMA and ALS motoneuron diseases
Spinal muscular atrophy (SMA) is an incurable paralytic neuromuscular disorder that mainly affects children at an incidence of 1 in 6000 to 10000 births. SMA is characterized by the selective degene
Novel treatment strategies for autosomal dominant chronic mucocutaneous candidiasis
Autosomal dominant chronic mucocutaneous candidiasis (AD-CMC) is a rare and severe primary immunodeficiency that is characterized by mucocutaneous fungal infection, autoimmunity, cerebral aneurysms,
Repurposing biomolecules for the treatment of epidermolysis bullosa
This proposal deals with new therapeutic approaches for a rare, disabling genetic skin disease, dystrophic epidermolysis bullosa (DEB). The hallmark of DEB is skin blistering induced by minor friction
Preclinical approaches towards therapeutic intervention for fragile X premutation carriers
The Fragile X gene (FMR1) is polymorphic for the number of CGG trinucleotide repeats in its 5’-untranslated region. Repeat sizes in the general population range between 5-55 CGG repeats. In Fragile
