Prerequisite for therapeutic management of sequels from AbdomiNo-pelvic radioTHrapy by local injection of MSC combined with a hydrOgel and an HS-mimetic – ANTHOS
Radiotherapy is still an indisputable component of the management of malignant pelvic diseases. It represents an optimal compromise between control of the tumour and damage to healthy tissue surroundi
Toward an alternative anticancer therapeutic strategy targeting the Hedgehog pathway using the dependence receptor paradigm – DepR-SHH
Dependence receptors (DRs) are transmembrane receptors which trigger apoptosis in the absence of their ligands. They have been shown to act as conditional tumor suppressors (Mazelin et al., Nature, 20
Immuno-Genetic, Inflammation, retro-Virus, Environnement : from etiopathogeny of major psychoses to animal models – I-GIVE
Mental illness is a major public health burden worldwide needing urgent research actions. Bipolar disorder (BD) in particular, is known to be associated with substantial functional impairment, high he
Depression is a polygenic and highly complex psychiatric disorder that is currently a major burden on society. Depression is highly heterogeneous in presentation and frequently exhibits high comorbidi
Serotonin Reuptake Inhibitors (SRIs)-type antidepressants, among which Prozac is the most known, are used from the 80's to treat depressive states. The molecular basis of the beneficial effect afforded by SRIs consumption as well as mechanisms of resistance to SRIs are still enigmatic. The aim is to identify such mechanisms to improve therapeutic approaches to combat depression.
LysoProd project concerns the establishment of an experimental prototype for the production of a functionalized enzyme drug that can be transferred to an industrial level for the treatment of Pompe di
Because of their very light weight, excellent in-plane properties and high specific strength, Carbon Fiber-Reinforced Polymers has found many uses in structural applications. Nevertheless they are par
Multiscales texturation of polymer surface by laser structuring of the injection moulds: application of this technology to the polymer systems of drug delivery – TOPOINJECTION
Multi-scale topographic texturing of polymer parts by laser-structuring of injection molds : Application of the technology to the polymer parts used in medical supplies.
Innovation in Materials and PROcedures to create Value from the MUlti-REcycling of Asphalts – IMPROVMURE
The entire French road network (covering some 980,000km) is a potential source of several billion tons of asphalt mix aggregates, the term used in European standards to describe the granular materials