Physical Chemistry process for the synthesis of sustainable marine materials for the littoral preservation – EcoCorail
Used the calcareous deopist that formed in seawater under cathodic protection by impresed current as natural cement between marine sediments as sands, shells, stones in order to form a conglomerate reinforcing the base of seawall and beachs in order to delate the costal errosion.
Optimized functional properties for foamed particulate materials
Clinical trial phase IIa of the first APA inhibitor (QGC001) as central acting antihypertensive agent and development of new "Best in Class"APA inhibitors – CLINAPAI
Hypertension (HTN) remains still difficult to control: In France, only 50% of the hypertensive population is at the blood pressure (BP) target, more than 25% of the hypertensive patients more than 3 a
Rational optimization of an innovative survivin therapeutic synthetic vaccine for treatment of cancers – OPTIVAX
Tumors often escape and even exploit the immune system to promote their survival, expansion and metastatization. However, tumor-specific T-cells retain the potential to effectively control and even er
Use a short sequence of an extracellular matrix protein named laminin involved in cell adhesion and migration, to favour the epithelialisation phase during cutaneous wound repair.
The aim of the project is the development of a new treatment for depression. Depression is a disease particularly frequent which can reach to 20% of the population in the industrial countries. The num
Based on experimental evidence, scientists have proposed that tumors may possess cells similar in phenotype to normal stem cells and that these cancer stem cells (CSCs) are the origin of tumors. Cance
Hemophilia is caused by a deficiency in factor VIII or IX. It is treated by the infusions of substitution products that cause the appearence of inhibitory antibodies in up to 30% of the cases. This limitation gave an oppportunity to developp alternative therapies.<br />Direct oral anticoagulants (DOA) target factor X and are used without antidotes. This creates threatened situations particularly in case of trauma-induced bleeds.
Optimising CNS-targeted neurotensin-peptide-vector conjugates for induction of therapeutic hypothermia – VEC2Brain
Central Nervous System (CNS) diseases are the world’s leading cause of disability. The brain's blood vessels possess unique anatomical and physiological features - collectively known as the blood-brai
With the recent discovery of biased ligands for GPCRs, new possibilities are available for the development of more specific therapeutics acting on GPCRs. It is then necessary to precisely study signal transduction pathways of any GPCR in its native environment. Our main goal is to develop such assays.