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A new class of antibiotics inhibiting bacterial trans-translation – antibio
Our research project focuses on the development of new broad-spectrum antibiotics that target the main quality control mechanism of bacterial protein synthesis : trans- translation .
A new model of innate immune response regulation by the nucleotide metabolism – INNATENUCLEOTIDES
Innate immunity, an essential arm of the immune system, must be kept under tight control to avoid adverse effects to the host, such as immunodeficiency or autoimmunity. Although the metabolism of cellular nucleotides and DNA repair was recently linked to the regulation of innate immune responses, the mechanisms underlying its deregulation are unclear. It is crucial to identify such mechanisms to better understand some human pathologies.
A novel nicotianamine-based metallophore in pathogenic bacteria – ANIBAL
Ensuring the availability of a given metal for growth is a vital microbial process, especially critical when the source becomes scarce like inside a host. Here, we present a project that is dedicated
A replay-driven model of spatial sequence learning in the Hippocampus-PFC network using reservoir computing – SPAQUENCE
In a complex environment, animals and humans learn to navigate between sequences of significant places. Such spatial sequence learning has been shown to involve brain areas including the hippocampus (
A role for endocytic proteins in muscle mechanotransduction – EndoMechano
Autosomal dominant Centronuclear myopathy (CNM) is a rare neuromuscular disorder due to mutations in the DNM2 gene coding for Dynamin 2 (DNM2). We have demonstrated that the ubiquitous clathrin heavy
A spin-photon interface: quantum entanglement and quantum measurements – SPIQE
The main goal of the present project is to investigate both experimentally and theoretically the potential of a semiconductor spin-photon interface for quantum information processing. Our objectives r
AGuIX® theranostic nanoparticles for vascular-targeted interstitial photodynamic therapy of brain tumors – PhotoBrain
Photodynamic therapy (PDT) for brain tumors appears to be complementary to conventional treatments. Numerous studies show the major role of the vascular effect in PDT tumor eradication. For interstiti
ALTER-TRACK – ALTERnative TRACKing
Positioning and fleet tracking systems are very extremely dependant on satellite networks to work, both for the position and its transmission.<br />The project aims at breaking those strong limitations by designing a comprehensive solution dependable, reliable and resilient for vehicule tracking.
ARCTIC climate change and its impact on Environment, infrastructures and Resource Availability – Arctic-ERA
ARCTIC-ERA will address critical aspects of human well-being and sustainable use of Arctic infrastructure and resources under the conditions of regionally accelerating global warming. The ongoing and
ARTificial protein Engineering for Metamaterial Integration and Self-assembly – ARTEMIS
The tailoring of optical properties has reached the nanometer-scale with the advent of plasmonics, the technology exploiting the collective properties of surface electrons in noble metals. It occurred