In plant and animal innate immunity, individual cells express receptor proteins to discriminate between pathogenic and non-pathogenic organisms. Pattern recognition receptors (PRRs) bind conserved pat
Novel strategies for efficient carbon capture and release by metal-organic frameworks using computational methods – Computationalcarboncapture
Carbon dioxide generated from the combustion of fossil fuels is a major contributor to climate change. To this respect, the implementation of efficient carbon capture technologies will allow for the continued use of fossil fuels in the near term, while renewable energy resources<br />gradually replace our existing infrastructure.
Novel drugs and drug combinations against bacterial growth, survival and persistence from high-throughput screening to mechanism of action – Combinatorials
Control of bacterial infections is threatened by the rapid emergence of drug resistance, drug tolerance that mitigates antimicrobial efficacy, and the lack of new antibiotics in recent years. Combinat
Infectious diseases are a major public health problem, and identification of novel potential therapeutic candidates is mandatory in a context of growing antibiotic resistance. As classical infection b
Vertebrate development is orchestrated by complex gene regulatory networks (GRNs), which remain largely unexplored. Redundancy within protein families, paralogous genes swapping across species and fai
This project is oriented toward numerical analysis and scientific computing for large scale simulations of electromagnetic wave propagation in harmonic regime on parallel architectures. It aims at dev
Non-invasive manipulation of brain synchrony to boost brain function and rehabilitate faulty visuo-spatial cognition in humans – OSCILLOSCOPUS
Abnormal oscillatory activity has been found to underlie cognitive impairments resulting from brain damage. Yet to date, no consistent attempt has aimed to better understand the causal basis of brain
Non-glycolytic pathways in glycosomes: novel functions for trypanosome development and virulence – GLYCONOV
Trypanosomatids are parasites transmitted by insect vectors responsible for major human diseases, which represent ~24 million infected people worldwide. However, there is no vaccine and few drugs have been developed. The unconventional biological processes developed by these parasites, such as the glycosomal metabolic pathways studied here, are considered potential targets for the development of new drugs. It is in this process that the GLYCONOV project is positioned.