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Analyse of sustainibility and reorganisation of Arabian coastal Neolithic socio-ecological systems during the mid-Holocene period (6.2-2.8 Ka BCE)
NeoArabia is an interdisciplinary and multi-scalar project, dealing with the very long term of the Arabian Neolithic (6200-2800 BC). Focused on environments and the mobility of coastal human communiti
Peptide-based metal complexes mimicking metalloenzymes activity
Catalases (CAT) and superoxide dismutases (SOD) are antioxidant metalloenzymes necessary for life in oxygen-metabolizing cells to regulate reactive oxygen species (ROS) levels. CAT and SOD take advant
Using the most powerful explosion as probes of the high-redshift Universe
Thanks to their exceptional brightness, the afterglows of gamma-ray bursts (GRBs) can be used as extra-galactic background sources capable of unveiling the properties of the universe at different redshifts. The class of long GRBs (LGRB) is associated with the collapse of the most massive stars, making them a tool to investigate star formation in the early Universe.
Polymer nanostructures with aggregation-induced emission properties for bioimaging and drug delivery
Polymer nanostructure-based bioimaging systems possess many advantages over traditional ones in terms of sensitivity, signal stability, multiplexing capability and facile surface functionalization for
Modular Consistency and Co-Designed Massive File System
RainbowFS proposes a “just-right” approach to storage and consistency, for developing distributed, cloud-scale applications. Existing approaches shoehorn the application design to some predefined con
Human genetic dissection of Mendelian susceptibility to mycobacterial disease
Mendelian Susceptibility to Mycobacterial Diseases (MSMD) is a primary immunodeficiency characterized by severe disease caused by weakly virulent mycobacteria, such BCG vaccines and environmental myco
CHCHD10 mutations: how mitochondrial dysfunction leads to motor neuron disease
Recently, we provided genetic basis to support the conclusion that mitochondrial dysfunction can have a causative effect in motor neuron degeneration. We reported a large family with a mitochondrial m
The divergent role of EGF and TGFa in chronic kidney disease: towards new therapeutic targets
Chronic kidney disease (CKD), a major socioeconomic worldwide public health burden, is characterized by a progressive decline in renal function to end stage renal disease that can occur irrespective o
Rabies virus RNA capping machinery as antiviral target
Mononegavirales such as Ebola, rabies, VSV and measles virus are non-segmented negative strand RNA viruses causing important public health threats. Although prophylactic or post exposure vaccination i
New generation of bright fluorogenic RNA probes for sensitive gene expression monitoring in live-cell imaging experiments
The homeostasis of the cell and its adaptation to environmental changes rely on tight and coordinated gene expression regulation occurring especially through pathways, which involve not only proteins
