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Synthèse de nouveaux nitroxides pour le diagnostic et l'étude de pathologie chez le petit animal via l'activité des protéases vue par IRM et effet Overhauser. – NITROMRI
No non-invasive spectroscopic techniques as efficient as MRI and suitable to monitor the enzymatic activity in tumors are available. This project aims to develop a new technique of MRI: the Overhauser-enhaced MRI which amplifies the conventional signal and is suitable for investigating in vivo the enzymatic activity.
Cellular tools for the discovery of new drugs for metabotropic glutamate receptors – Glusense
General presentation: Important drug targets today are the metabotropic glutamate receptors (mGluRs). These receptors have been linked with neurological and psychiatric disorders such as absence ep
Enhanced anaerobic digestion – DANAC
By a bio-mimicry approach, the project aims to improve the anaerobic digestion processes using animal models, both at the level of processes and at the level of microbial communities. This multidisciplinary approach combines: modeling of different digestive systems, copies of two laboratory-scale digestive systems and structural and functional description of the associated microbial communities.
Adapting T. reesei cellulolytic enzymes for Simultaneous Saccharification and Fermentation – ACTIFE
Combination of lignocellulosic biomass hydrolysis and fermentation steps can lead to lower process costs for the 2nd generation bio-ethanol industry, but also brings constraints to the enzymes' activities. The objective of this project is to adapt several enzymes to these constraints.
Amélioration du plaisir alimentaire du senior pour bien vieillir et lutter contre la dénutrition – AUPALESENS
Les raisons de la malnutrition sont multifactorielles : déclin des capacités sensorielles,changement des préférences alimentaires, facteurs sociaux, environnementaux , pathologiques… il est donc important de proposer des outils d’amélioration des repas pour mieux répondre aux attentes des personnes âgées et aux besoins liés au vieillissement.
Nouvelles stratégies de marquage paramagnétique pour l’étude des transitions structurales dans les protéines désordonnées – SPINFOLD
Development of new paramagnetic probes to determine by EPR spectroscopy the dynamic and structural properties of disordered<br />proteins at nanometric scale. Thanks to the diversification of the grafting sites and of the spectroscopic signatures brought by these new probes, it is now possible to develop Biostructural EPR methods well adapted to<br />the study of flexible proteins and of large size biological systems.
Le rôle des ions métalliques dans l'agregation, la production de radicaux et la toxicité du peptide amyloïde-? – Neurometals
It was shown that copper and zinc ions play a key role in the aggregation of A? peptides and neuronal toxicity. The purpose of this project was to understand the role of copper and zinc ions in the two key stages of AD development as well as the molecular mechanisms they are associated
