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Role of cAMP signalosomes in cardiomyocyte senescence and age-associated heart failure
The increase in longevity is associated with a wider prevalence of heart failure with preserved ejection fraction (HFpEF). While the incidence of HFpEF in terms of mortality is constantly growing, treatments remain unsuccessful because of insufficient knowledge on the mechanisms of cardiac ageing. In an original approach, our consortium proposes to develop and share appropriate models to better understand HF in the context of ageing.
Tissue specificity of paradoxical effects of anti-TNF therapy in inflammatory bowel diseases
Systemic manifestations are a hallmark of chronic inflammatory diseases, as bone destruction in inflammatory bowel disease (IBD). Anti-TNF-a therapy is the first-line of treatment for IBD but despite its efficacy in the gut and bone, it induces psoriatic skin lesions. In addition of serious consequences for patient care, this side effect raises the question of the tissue specificity of the control of inflammatory responses that remains largely unknown.
Evolution of X-inactivation and regulatory lncRNA in primates
The noncoding fraction of genomes is likely to contribute to phenotypic diversity among closely related species, given its role in gene expression regulation and its rapid turnover in evolution. Here we aim to explore how the noncoding genome allows for rapid adaptation and species-specification on a short evolutionary timescale, using the X chromosome inactivation process as a paradigm.
Structure and molecular function of the pseudopilus in type 2 protein secretion pathway
Synergy_T2SS aims to decipher the structure and function or the pseudopilus - the dynamic motor of type II secretion system, and that in three model bacteria.The current models of the secretion mechanism - «piston« and «archimedes' screw« predict different pseudopilus dynamics and interactions with the secreted substrates. We aim to test these prediction using integrative approaches, and to propose a unified and experimentally validated model of type II secretion mechanism.
High-temperature & high-polarization cuprate multiferroics
Magnetoelectric multiferroics which combine electric and magnetic dipole orders, are multifunctional materials with high potential in new technologies. It can be used to reduce computer memory energy consumption, to improve magnetic field sensors or in spintronic applications. Unfortunately, too few ME crystals are known to date, and even less could lead to industrial applications. Indeed, they usually give a small response and need low functioning temperature to exhibit the desired properties.
The memory of riverine sediments used to predict the environmental impact of new technologies
The memory of riverine sediments used to predict the environmental impact of new technologies
Optimising the use of discretionary salt
Reducing sodium intake has been identified as an efficient lever to prevent noncommunicable diseases. Key sources of sodium include manufactured food products but also discretionary salt, namely salt added by consumers during the preparation and cooking of meals and at the table when seasoning. However, discretionary salt has been largely neglected so far, in spite of the fact that it deserves to be considered to pursue the sodium intake reduction.
Enhancing the Quality and the Level of Internal Protections of Shell Eggs
The EQLIPSE project is positioned in the context of extension of the production period of laying hens. In particular it aims to study the consequences of this extension on the quality and natural defenses of eggs and to identify levers to control internal alterations induced by hen age and egg storage conditions.
Molecular mechanisms of temperature sensing in plants
How plants sense temperature is a fundamental question in plant biology. In this project we are investigating the molecular and atomic level determinants of temperature sensing mediated by the protein EARLY FLOWERING 3 (ELF3). ELF3 undergoes reversible liquid-liquid phase separation (LLPS) as a function of temperature. We are determining the structural basis of LLPS, how temperature effects ELF3 phase separation and introducing targeted mutations to alter LLPS in vitro and in vivo.
The gene set defining the diatom chloroplast
BrownCut<br />Elucidation of photosynthesis-specific genes in diatoms
