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Big Data reduction for predictive computational modeling
The DataRedux project focuses on developing radically new methods for the reduction of the complexity of large networked datasets to feed effective and realistic data-driven models of spreading phenomena.
Molecular and evolutionary principles governing enzyme regioselectivity
Prediction of enzyme function is a notoriously difficult problem with promising biotechnological impact. Here, we tackle this problem by studying both molecular mechanisms and evolutionary properties of a class of enzymes that are involved in the ubiquinone biosynthesis pathway. To that end, we propose an interdisciplinary approach consisting in confronting bioinformatics studies in evolution (comparative genomics), biophysical models of molecular dynamics and biochemical experiments.
Access to informational content of texts by children
The TextToKids project aims to facilitate the writing and the filtering of texts for children, especially but not only in order to tell them about current events (e.g., presidential elections, Brexit, reception of migrants in France, etc.) in respect of their language skills. The targeted age group is that of young readers, that is, the 7-12 age group.
A One health study of Monkeypox: Human infection, animal reservoir, disease ecology and diagnostic tools
The understanding of monkeypox still has many grey areas: the animal reservoir is not identified, the risk factors for zoonotic and human-to-human transmission, and the ecological conditions favorable to its emergence are not fully described. Our multidisciplinary project will be grafted on the national surveillance process of monkeypox and will allow a holistic approach of this disease through multiple complementary approaches.
Role of Sting in lymphocyte development and function
STING drives type I interferon (IFN) and inflammatory responses. Patients with STING gain of function (GOF) mutations develop an autoinflammatory disease (SAVI). We reported a new mouse model of STING GOF, with severe type I IFN-independent combined immune deficient (SCID) phenotype, affecting all lymphoid lineages, with lymphoid functional defects partly described in SAVI patients. We propose to characterize the mechanisms underlying the new role of STING in lymphoid development and function.
Plasmodium sporozoite neutralization in the host skin
Plasmodium sporozoites (SPZ) are motile forms of malaria-causing parasites transmitted by the mosquito into the host skin . SPZ motility is essential to access the blood circulation and can be inhibited by antibodies against the circumsporozoite protein (CSP). Recently, we discovered anti-CSP cytotoxic antibodies that target SPZ in the skin. Here, we intend to characterize how and what antibodies are neutralizing SPZ in the tissues and correlate their in vitro activities with protection in vivo.
Hijacking of the HAUSP/p53 pathway by the Toxoplasma protein GRA16: a mechanism regulating p53-dependent metabolism, cell fate and immune signaling during toxoplasmosis?
Basic research effort aimed at better understanding the parasite Toxoplasma gondii's interference processes with its host. The findings of this investigation will allow researchers to investigate novel toxoplasmosis prevention and treatment options.
Mechanics of Embryonic Self-Organization and Plasticity
Characterization of the mechanical forces at play during the self-organized development of the vertebrate embryo
spreading of granular pastes: from the particle to end use properties
Granular pastes such as gypsum pastes or fresh concrete play an important role in the manufacture of various products in the construction, chemical and food industries. These materials are non-Newtonian fluids whose complex rheological properties need to be understood and described with the help of physical models in order to optimise the end-use properties of these products in conjunction with their formulation.
Tribological reliability of amorphous metallic alloys
Tribological reliability of Bulk Metallic Glasses
