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LIPOMEC: TOWARDS A BETTER UNDERSTANDING OF RUMINANT MILK LIPOLYSIS THROUGH AN INTEGRATIVE BIOLOGY APPROACH IN MILK AND MAMMARY EPITHELIAL CELLS (MEC)
Milk lipolysis is the breakdown of milk fat by an enzyme, the lipoprotein lipase, resulting in the release of free fatty acids in milk. This may lead to the development of a rancid flavor in milk considered unacceptable by the consumer beyond a certain threshold. Moreover, the presence of partial glycerides in milk interferes with technological processes in the industrial processing of dairy foods. It is therefore important to limit lipolysis to preserve the quality of milk.
Live-tracking rhizobial switch from rhizosphere to plant-confined colonization modes
Legumes establish a beneficial root nodule-forming nitrogen-fixing symbiosis with rhizobia for improved growth. The early stages of this interaction involve key molecular exchanges and the reprogramming of plant cells for bacterial entry. However, little is known about how rhizobia cope with the drastic shift to a confined host environment at this stage. Live-Switch addresses this question by studying the reprogramming of rhizobia and the dialogue with the plant partner at the single cell level.
Pre-clinical research for diseases caused by IM dysfunction.
Pre-clinical research on diseases caused by IM dysfunction.
Mitochondrial and protease dysfunction in progeroid Cockayne syndrome cells and during age-associated processes
Understanding the molecular defects responsible for premature ageing diseases like Cockayne syndrome (CS), is critical to develop treatments, which are dramatically missing to date, and also elucidate physiological ageing. We identified an altered pathway that involves mitochondrial an metabolic dysfunction in cells from CS patients, and rescued these defects in these cells, by scavenging oxidative/nitrosative molecules, paving the path to therapeutic approaches for CS.
Surface and volume modulation of fast deforming cells and organelles
Cells are often described as almost spherical objects. However, the dense environment of the tissues keeps them away from this simple shape. Cells can undergo rapid deformation as they migrate through dense tissue and as they move through blood capillaries. In this project, we propose to study the large deformations of cells, the associated responses and their importance for the migration of immune cells.
Redox modulation of rhodium-catalyzed nitrene insertions into C(sp3)-H bonds
We plan to design new dirhodium(II) complexes in order to develop a more efficient and subsequently enantioselective intermolecular amination of C(sp3)-H bonds in the context of sustainable chemistry. Our approach will be based on a mechanistic study from the point of view of the design of the catalysts, and the influence of the electronic properties of the ligands on their efficiency, selectivity and stability.
Decision system for smart management of resources in warehouses
The project AGIRE addresses the human resources management in warehouses which supply either sale points (B2B) or final consumers (B2C). Such warehouses are under pressure due to the no inventory policy at the sale points and to the constant growth of e-commerce sales. In terms of logistics, this translates into an increasing number of parcels to prepare and to ship to satisfy an order, which is known typically a few hours in advance.
Measurement and optimization of lattice materials
Modeling and Optimization of Periodic Architectured Materials
Microstructure and mechanical properties of polycrystalline nickel-base superalloys of the aerojet engines of the future
Capable of higher operating temperatures, new polycrystalline nickel-based superalloys are used for new generation aircraft engines. To take full advantage of the performance of these materials, the microstructure changes occurring during the forming operations must be perfectly controlled and lead to the optimal microstructure, to be defined according to the targetted in-service conditions.
Surface Integrity Mastering for machined surfaces
Surface Integrity Modelling for Machined Surfaces
