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A genetic approach to decipher the role of T-type calcium channels in neuropathic pain
The detection and processing of painful stimuli in afferent sensory neurons is critically dependent on a wide range of different types of voltage and ligand gated ion channels, including sodium, calci
A highly Sensitive 99mTc-NTP 15-5 SPECT imaging targeting proteoglycans for assessing ostearthritis response to innovative therapeutic approaches.
Osteoarthritis (OA), in the context of an aging population, has a major impact on the quality of life of patients and is a very significant health problem in western countries. OA is a slowly, progres
A holistic brain injury rehabilitation digital system of cognitive networks
Traumatic brain injury (TBI) is a condition that leads to multiple disabilities. The heterogeneity of cognitive disorders and their persistence even at very long-term make care of the TBI difficult. At this, adds the lack of rehabilitation tools. The SYNCHRO-TC project responds to this problem by developing a software platform for managing rehabilitation, taking into account the heterogeneity of these disorders, hence makes easier to ensure quality care for patients.
A new approach to inhibit ErbB2 signaling and design new drug candidates: targeting the EGF domains of its membrane partner, the MUC4 mucin
The general goal of the DRUG_MUC4 project is to study the structure-function relationship of the MUC4-ErbB2 complex and propose new small inhibiting therapeutic molecules targeting MUC4-EGF domains.<br />The aberrant overexpression of the transmembrane MUC4 mucin, its partnership with ErbB2 and the negative consequences of the activity of MUC4-ErbB2 complex on epithelial homeostasis, has allowed identification of MUC4 as a highly attractive therapeutic target (Kufe, 2009).
A smart nanotechnology approach for the development of intelligent safety high performance textiles and clothing against chemical warfare agents and pesticides
Despite the international efforts aimed at regulating and lessening the use of environmentally toxic gas nerve agent, organophosphorus compounds(OP) are still used intensively as pest control agents a
A sociolinguistics of Twitter : social links and linguistic variations
The SoSweet project focuses on the synchronic variation and the diachronic evolution of the variety of French used on Twitter. SoSweet adopts a strong interdisciplinary position, at the crossing of social media linguistics, sociolinguistics, natural language processing (NLP) and network science. It is based on a dataset containing several hundred of millions tweets, together with a several millions users social network.
ACTIVe Reduction Of Aerodynamic Drag. Wake control : from passenger car to long haul vehicle
Active Reduction Of Aerodynamic Drag<br />Wake control: from passenger car to long haul vehicle
ADAPTATION OF PHYTOPLANKTON TO POLAR REGIONS: SURVIVAL STRATEGIES DURING THE ARCTIC WINTER
Phytoplankton is responsible for about half of the photosynthesis on the planet. In polar regions, phototrophic organisms need to survive during long periods of darkness occurring in winter. However s
