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Structure and impact of lipids on the 5-HT2A-mGlu2 heteromer, a schizophrenia drug target – Schizoceptor
metabotropic glutamate mGlu2 and the serotonin 5-HT2A were found to interact and form a heteromer in schizophrenic [...] little is known on the molecular mechanisms of 5-HT2A-mGlu2 heteromer formation and its functional interplay [...] fluorescence to understand how lipids and 5-HT2A-mGlu2 modulate each other's function.
Optimization of a flexible technological chaine of CO2/H2O co-electrolysis and CO-hydrogenation into synthetic methane – CHOCHCO
and CO2 into a syngas made of H2 and CO) 2) a catalytic methanation block 3) and probably, a methane [...] project deals with the issue of CO2 value chain and with the development of a novel family of solutions for [...] this solution enables to build a carbon circular economy by enhancing CO2 value. The “Power to Methane”
New Antiviral approach against SARS-CoV2 by Targeting the RNA helicase DHX9, a cofactor of SARS COV-2 – NAT_DHX9
Dr. Briant, we set-up a model of SARS-CoV-2 infection using Vero E6 and A549-ACE2 cells. In our preliminary [...] consider DHX9 as a potential therapeutic target for the development of anti-SARS-CoV-2 molecules. In c [...] of the SARS-CoV-2 virus and that our DHX9 inhibitors demonstrated strong anti-SARS CoV-2 antiviral properties
Inhibition of SARS-Cov2-S - ACE2 interaction AS A THERAPEUTIC TARGET – ACE2-S-Cov
interacts with angiotensin-converting enzyme 2 (ACE2). ACE2 is an essential component of the renin–angiotensin [...] the effect of a series of patented molecules targeting the SARS-CoV-2 -S protein / ACE2 interaction. It [...] severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become pandemic, in the absence of an
Analysis of the spatio-temporal variability of pCO2 and air-sea flux of CO2 over the global coastal ocean during the last two decades: a satellite approach – CO2COAST
carbon fluxes are such, that the CO2 flux in the coastal margins remains a poorly constrained term in global [...] objectives of CO2COAST are to estimate, for the first time, the global coastal waters CO2 flux from satellite [...] to the estimation of pCO2 from space, although convenient to develop, present a regional character that
A2A receptors and Tauopathy – ADORATAU
of interest in a therapeutic perspective. With this regards, adenosine A2A receptors (A2AR) are targets [...] al data linking A2AR to Tau pathology. Indeed, global genetic blockade of A2ARs in a Tau transgenic mouse [...] showing that A2A receptor expression is increased in the brain of AD patients. However, A2ARs are not only
Synthesis and applications of planar chiral photoredox catalysts based on a [2.2]paracyclophane scaffold – PhotoChiraPhane
As a consequence of their rigid three-dimensional structure, deck-substituted [2.2]paracyclophanes (pCps) [...] transformations. The rigid [2.2]paracyclophane unit will serve two key functions: a) ensure close proximity [...] (the scientific coordinator, and a member of her team), together with a PhD student, who will be hired
Targeting A2A receptor in autism: single domain antibodies for direct inhibition or antagonist vectorization – A2utismAb
Among adenosine receptors, the A2A receptor (A2AR) is a G-protein coupled receptor (GPCR) that receives [...] receives raising attention as a therapeutic target in multiple pathologies. Brain A2AR expression is quasi [...] either for the target or for a particular tissue, allowing a better efficacy and a reduction of side effects:
Greatwall/ENSA/PP2A-B55: A new pathway in the control of S phase progression and the DNA damage checkpoint – REPLIGREAT
We identified a role of the Greatwall(Gwl)/ENSA/PP2A-B55 pathway in S phase control via the regulation of the stability of Treslin, a master replication factor controlling origin firing. Our preliminary data also suggest an impact of this pathway in the stability of additional proteins controlling replication fork progression. Moreover, because its capacity to modulate Treslin stability, this pathway could participate to late origin firing inhibition upon intra S phase checkpoint activation.