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This academic/industry collaborative partnership should contribute towards the goals of the challenge «health & wellness» (axis: Translational research in Healthcare). Cancer is the 2nd cause of mortality in France and worldwide. SELECTIMMUNONCO aims at characterizing and comparing the different i

Preeclampsia is a hypertensive disorder of pregnancy associated with important maternal and perinatal mortality and morbidity. It complicates 2 to 7% of pregnancies and causes more than 70 000 maternal deaths each year worldwide. Although symptomatic management has improved there is currently no cur

Central hypoventilations encompass several neuro-respiratory diseases that result from neurologic disorders. The cause of central hypoventilations may be congenital or acquired. Hypercapnia, acidosis and hypoxemia which result from central hypoventilations have deleterious effects on cardiovascular

Dysregulation of local ocular iron metabolism leading to iron excess is now considered as important contributor to the pathogenesis of neurodegeneration diseases. Age-related macular degeneration (AMD) is the most common cause of irreversible vision loss in the elderly worldwide, involving both gene

The project is to develop an innovative multimodal technology acquisition and multispectral imaging for early detection and characterization of mucosal inflammation preferentially occurring in two areas of the stomach, distal portion (antrum) and the junction with the esophagus (cardia). These infla

Legionnaires’ disease (LD) due to Legionella pneumophila serogroup 1 (Lp1) is an important cause of community- and hospital-acquired pneumonia. Development of man-made water systems created aerosols allowing the direct access of this opportunistic bacterium to human lungs. Thus LD became an emerging

The project “teenage obesity” (OBETEEN) aims at providing France and Mexico with high profile research concerning the neurocognitive impact of juvenile obesity. Current surveys attest that the obesity epidemic is reaching an alarming level since about 45% of French adults and over 71% of Mexican a

Non-alcoholic fatty liver diseases (NAFLD) include several entities ranging from simple steatosis to hepatic fibrosis or cirrhosis. Steatosis, considered benign and the first stage of the disease, is characterized by the accumulation of triglycerides in the liver. It may in some cases progress to no

Listeriosis is a rare and severe infection caused by the bacterium Listeria monocytogenes (Lm). It manifests as a blood infection (septicemia), central nervous system (CNS) infection or maternal-fetal (MF) infection. Diagnosis relies on the culture of biological samples (blood, cerebrospinal fluid,

Project abstract IInflammatory Bowel diseases (IBD), such as Crohn’s disease (CD) and ulcerative colitis (UC) are characterized by chronic and relapsing inflammation of the intestine due to dysregulated immune responses to commensal bacteria. Their incidence and prevalence are high in western count

This translational research project aims at defining the role of iron deficiency in tissue damage during celiac disease (CD) with the goal to provide new recommendations for the care and prevention of this frequent disease affecting 1% Caucasians. CD is a complex autoimmune-like disorder induced in

Intracranial aneurysm (IA) is an asymptomatic cerebrovascular abnormality affecting 3.2% of the general population. The devastating complication of IA is its rupture, resulting in subarachnoid haemorrhage that can lead to severe disability and death. Unfortunately, there are neither reliable clues n

Post-Traumatic Stress Disorder (PTSD) is a serious chronic and debilitating psychiatric disorder that can develop following exposure to a traumatic or stressful event. To date, there is no specific and efficient treatment for PTSD, and the current medications based on antidepressants are not affordi

The GenRed project aims to identify germline mutations that cause hereditary (HE) and idiopathic erythrocytosis (IE). These rare hematological diseases are characterized by excessive production of red blood cells. HE/IE can be complicated by thrombotic events, bone marrow fibrosis and rarely tumors.

Stroke is the third cause of mortality and the first cause of handicap. Thrombectomy is about to change patient care in emergency. In this context close to myocardial ischemia-reperfusion (IR), treating reperfusion injury is crucial as it contributes to cell damage extension and to inflammation. In

Escherichia coli is the first causative agent among community-acquired bacteraemia and the 5th among hospital-acquired bacteraemia. E. coli bloodstream infections (BSI) account for an overall mortality rates ranging from 5% to nearly 30%. The determinants associated with severe outcome and death rem

BACKGROUND: The incidence of autoimmune type 1 diabetes (T1D) is steadily increasing in Western countries (4% annual increase in France), affecting children of younger age and imposing a growing toll in terms of quality of life, long-term complications and public heath expenditure. Its environmental

The Tricho-HepatoEnteric syndrome (THE) is a rare congenital disease associating intractable diarrhea, facial dysmorphism with hair abnormalities, intrauterine growth restriction, immunological defects and hepatic disease. The Ski complex is a heterotetramer identified in yeast and composed of Ski2,

Chronic heart failure (CHF) is a major public health care problem with a prevalence estimated at 1 to 2% of the adult population in developed countries. Although there have been important therapeutic improvements, the mortality of CHF remains high especially for the more severe forms of the disease.

Rotaviruses (RVAs) are the most common cause of acute gastroenteritis in children. The disease frequently requires hospitalization and annually causes the death of several hundred thousands children in low-income countries. Two live vaccines have been developed and both show remarkable efficacy in h

Pompe disease (GSD-II) is an inherited recessive metabolic myopathy (incidence: 1/40,000) caused by mutations in the GAA gene encoding the acid alpha-glucosidase enzyme. We here developed an entirely new concept for treating the majority of patients with Pompe disease based on a RNA splice modificat

Although tyrosine kinase inhibitors (TKIs) can produce high objective response rates in molecularly-defined patients, their long-term efficacy is limited by the development of resistance. In patients with non-small cell lung cancer (NSCLC) harboring activating mutations of EGFR (epidermal growth fac

This "COSMIT" project focuses on a rare disease, the Costello syndrome (CS), the underlying mechanisms of which are not understood and for which no treatment is available. This rare disease is revealed in the first months of life and is characterized by postnatal growth retardation, thick lines, int

Systemic Lupus Erythematosus (SLE) is a multifactorial autoimmune disease affecting multiple organs that could lead to death when the kidney damage (lupus nephritis, LN) is confirmed. LN is characterized by glomerular deposits of IgM, IgG and IgA autoantibodies-containing circulating immune complexe