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The purpose of this project is to explore new out-of equilibrium topological phases. This project aims at developing theoretical tools to characterize the topological properties of periodically driven systems and to identify their physical signatures. The search for these dynamical states and the

The project is devoted to the study of Kinetic Mean Field Games (KMFGs), i.e. the limit of cooperative or non-cooperative games in very large populations, composed of interacting individuals, where each individual has a small influence on the global behaviour of the system and where the behaviour of

Resilience to genetic or environmental insults results in phenotypic invariance among the individuals of a population, or “phenotypic robustness”. Yet, for evolution to occur there must be heritable phenotypic variation among individuals. Population genetic theory indicates that stabilizing selectio

The conventional view held by many, that rivers are the only source of land-derived freshwater and solutes to the coastal zone will be challenged in this project. Coastal aquifer systems extend underneath the coastline, and groundwater originating from these aquifers is an additional pathway for nut

The overall objective of this project is to compare the implementation of the UNESCO ICH Convention in three case-study countries (Greece, Brazil and China) across: 1. The international arena where policy principles are negotiated (UNESCO); 2. National heritage institutions where international n

A fundamental property of animal cells is their ability to form coherent yet highly dynamic tissues. While the migration of single cells on extracellular support is quite well understood, the movement of cells within compact tissues remains mysterious. In this mode of migration, called “intercellula

Understanding the conditions for the emergence and the maintenance of diverse life forms is a major goal of evolutionary biology and ecology. Adaptation to different environmental conditions or different niches is one of the prominent explanations to account for the diversity of life. However, the p

The specific objectives of the project are: 1. Developing a field-based model of bluefin tuna/tropical tuna vertical/horizontal behavior in the NWM/in the Atlantic and Indian ocean, respectively. This model will allow connecting the individual behavior recorded by electronic tags to the observation

Task (A) Researching on functional glasses Involves the fabrication, purification and characterization of hybrid phosphate glasses with new or interesting properties (ex. laser damage resistance, incorporation of transition ions for high nonlinearity); investigation of their structure/property relat

In the last ten years, great progress has been made in the study of preschoolers’ skepticism. Conversely, very little is known about the sources of trust in communication in infancy. The overarching goal of this project was to investigate the building blocks, scope, and origins of human trust in com

Polyphasic liquids (suspensions, emulsions, wetted foams) are ubiquitous in nature and industry (soils, pulps, pastes…). As for conventional liquids, there is an increasing need to optimize capillary flows of these liquids at smaller and smaller scales, with concern to both the overall polyphasic en

The proposed research activity gravitates around a simple idea, that of ``self-similarity'', and all its avatars in geometry, algebra, dynamics and theoretical computer science. It propounds the use of tools from algebra and theoretical computer science to answer questions and provide illumina

The East African Rift zone is the most distinctive actively rifting region on our planet. Within the rift valley there are active volcanic systems perhaps related to a deep source of hot mantle that is responsible for this volcanism and the current break-up. The central gap in our understanding is h

Although the discovery of antibiotics has been an important success story in medicine, the efficacy of conventional antibiotics treatments is decreasing due to global emergence of multi-drug-resistance (MDR) among major human pathogenic bacteria. The lack of new therapeutic options reflects the diff

The general aim of the EpiVirHep project was to investigate, the epigenetic changes that precede and accompany hepatocellular carcinoma (HCC) development and progression mainly, but not exclusively, in the setting of hepatitis B chronic liver diseases. Hepatocellular carcinoma (HCC) is the 6th mos

The first task is to extend and deepen the study of ABC-F family translation factors that my collaborators and I have characterized. We have shown that the EttA protein, belonging to the ABC-F family, modulates the dynamics of the ribosome in order to regulate the activity of protein synthesis as a

The research project is devoted to the study of the development of waves with extreme features, in different branches of science, with particular emphasis on nonlinear optics and laser physics. The focus is mainly on two processes, namely Rogue Waves (RW), that is the generation of waves of unexpect

Next-generation sequencing technologies have enabled rapid identification of many genes contributing to human disease. One of the major difficulties with this new approach is to prove pathogenicity of a given variant, making functional validation a top priority-issue in human genetics. The aim of th

The unprecedented growth of digital electronics over the past 50 years has largely been driven by Moore’s Law scaling of silicon integrated circuits, in which there is a dual improvement in device-on-chip density and transistor switching speed as device dimensions are reduced. However, ultimately, t

The ambition of evolutionary developmental biology (evo-devo) is ultimately to devise a mechanistic theory that would link the processes of individual development with phenotypic change during evolution. Typical evo-devo questions are for instance: how congruent are the genetic and phenotypic change

Cell fate choice and maintenance require a precise balance of gene activation and repression. An essential component in these processes is the selective formation and maintenance of repressive heterochromatin domains with long-term stability and minimal variation among individual cells. I and other

Adolescence is characterized by changes in skills, motivations, and social landscape, as well as in brain structure and function. But how these domains of plasticity are interrelated is unknown. Recent research focuses on the late development of brain regions involved in cognitive control compared t

Exocytosis is one of the fundamental physiological processes in the cell. Diverse and important functions like secretion of hormones or enzymes and release of neurotransmitters at the synapse require exocytosis. So, malfunction of this process can lead to many diseases such as diabetes or neurodegen

During the last 5 billion years (Gyr), the universe has been accelerating in its expansion due to a repulsive force that we have named ‘dark energy’. My goal is to understand the nature of this mysterious phenomenon that dominates our universe. Cosmologists are working toward achieving this goal by

Molecular dynamics simulations are currently a valuable tool to complement experimental techniques in the characterization of biomolecular dynamics. However, the contribution of MD simulations to our understanding of the behavior of cellular proteins is still extremely limited. In fact, proteins are

We want to characterize Mdm2 structure in its different phosphorylation status. Mdm2 is a ubiquitin-ligase, which has the tumor suppressor p53 as a main target. Hence, inhibiting Mdm2 is an attractive anticancerous strategy. Mdm2 contains both folded and disordered regions, and its activity is regul

The overall goal of this project is to successfully transfer the research activity of a well established, internationally recognized group to the new Paris-Saclay University, specifically to the LCM (Laboratory of Molecular Chemistry) of the Ecole polytechnique. The scientific focus of the project

1. We will focus on the structural differences in translation initiation between kinetoplastids and their mammalian hosts (i) by characterizing initiation complexes from several plasmodium and kinetoplastids species and compare them to their mammalian counterparts. We will also (ii) follow up on our

This project main objective is to improve our knowledge of plasma cell biology, from their generation in the secondary lymphoid organs to their long-term maintenance in survival niches, and by doing so to identify new ways to target and regulate this cell subset. Plasma cells are essential for the d

One of the unsolved challenges of synthetic and systems biology is bottom-up prediction of gene expression from molecular interactions of regulatory molecules with the genome. Current high-throughput experiments allow generating large data sets for retrieving the DNA sequence preferences of transcri