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There is currently an important lack of studies aiming at bringing together human genetics, gut ecosystem microbiology and environmental factors in the context of inflammatory bowel diseases (IBD). Changes in dietary consumption patterns affect many aspects of human biology, including the compositio

Pulmonary arterial hypertension (PAH) is a rare and devastating disease leading to right heart failure. PAH may be partly viewed as a disease of excess proliferation and impaired apoptosis of the pulmonary artery (PA) smooth muscle cell (PASMC) and endothelial cells (PAEC) leading to a cancer-like p

Background and objectives: Urolithiasis (renal stones) affects more than 10 % of the population in western countries and its prevalence is currently increasing. Renal stones result in repeated hospitalizations, and sometimes in kidney infections, chronic kidney disease, and renal replacement therapi

Our project consists in characterizing the AUNA1 auditory neuropathy mice model, in deciphering the Diaph3 signaling pathways and in developing rescue strategies in the transgenic mice. Our preliminary result shows that the two transgenic lines overexpressing Diaph3 protein, display progressive thre

Within the arterial system, the extracellular matrix (ECM) becomes more rigid with age, as a result of extensive modifications, including elastin depletion and calcification. This excessive ECM rigidity affects arterial wall cell phenotype and growth, leading to inflammation and vascular remodeling,

Context. Occidental countries have to face a dramatic expansion of metabolic diseases, including obesity and diabetes, representing a major health burden in industrialized societies. The rapid increase in prevalence of these metabolic diseases is likely due to changes in environment and lifestyle, g

The GENET-FMD project aims to identify rare and common genetic determinants of fibromuscular dysplasia (FMD), a non-atherosclerotic non-inflammatory rare arterial disease, predominantly described in renal arteries and extra-cranial carotid. FMD is the second common cause for renovascular hypertensio

Type 1 diabetes (T1D) is an autoimmune disease usually diagnosed at young age and characterized by the destruction of pancreatic beta-cells, the only cells capable of producing insulin. Although treatments may normalize blood glycemia, diabetes complications can still occur, especially because of th

Myeloproliferative neoplasms (MPN) are clonal malignancies caused by genetic defects that occur in the hematopoietic stem cell and result in overproduction of one or several myeloid lineages (i.e. erythoid, megakaryocytic and granulocytic). The MPN are classified into three broad categories: 1) chro

Immunoglobulins (Igs) that circulate under physiological conditions have the intrinsic capacity to bind to various biologically relevant or xenobiotic low molecular weight compounds. For instance, a significant proportion of circulating Ig binds to riboflavin with high binding affinity. A fraction o

The liver is a vital organ and a site of extraordinary exchange between blood from digestion and hepatocytes. These exchanges are made possible by a unique architecture of the liver capillaries, also called sinusoids, and by specific characteristic of liver sinusoidal endothelial cells (LSECs). LSEC

Background and Rationale In sub-Saharan Africa, preventive drug strategies against malaria in pregnancy are recommended from the 2nd trimester of pregnancy onwards. Consequently, pregnant women remain insufficiently or not protected during the first trimester of pregnancy. However, this period ma