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The ever-increasing need for better time synchronization in number of High-Tech and scientific applications calls for the development of new frequency references of improved stability. We demonstrated recently the potentiality of a new technology based on a microwave sapphire resonator cooled in a c
This project concerns a new type of spring with high resilience and high precision mechanical strength above 3 GPa up to 5 GPa. The behavior and configuration of these springs are based on the response of an arc (semi-circle) of vitrified metal constrained between two plates under a force perpendicu
For critical embedded networks like in avionics, automotive and satellites with hard certification requirements to respect and where a failure might have a disastrous consequence on the system, deterministic guarantees on temporal and functional constraints are of the utmost importance. Having the o
Development of an intelligent electromyostimulator for muscular conditioning – ELECSTIM
The purpose of this project is to develop a new tool for retraining the neuromuscular function in order to improve the effectiveness of strength training sesssions. This smart electromyostimulator using both electromyography (EMG) and electrostimulation (EMS) techniques enable to adapt in real time
Wide field-of-view video microscopy is intended for fast and repeated visualisation of the wells in a microtiter plate. Massive acquisition of images by the microscope can be exploited to determinate the evolution of several cell populations in the microtiter plate, for the purpose of quality contro
Inhibitors of Chemokine receptors as Anti-inflammatory Reagents in the Eye – I-CKAIRE
We identified the first short peptide called ECL1i with strong CCR2 antagonist activity. ECL1i blocks CCR2 activity without interfering with the natural ligand binding site, a major advantage compared to conventional non-peptide molecules and antibodies against CCR2 because ECL-1 antagonizes CCR2 in
Development of therapeutic monoclonal antibodies for the treatment of B cell non Hodgkin lymphomas – THERFL
Non-Hodgkin's lymphoma is the most frequent hematological malignancy and the sixth most common cancer of adults in France. Treatment efficiency remains poor and most patients still remain not curable. We have identified a novel marker for these tumors and we will assess whether an antibody recogniz
Development of integrated and parallelized microfluidc biochips in industrial format for xenobiotic screening – CCDIM
The objectives of the project is to develop a microfluidic platform in a compatible format for external end users. The targeted users are pharmaceutical compagnies. The intermediate goals are -The selection of a material suitable for the biochip fabrication allowing cell biology and mass produc
Fast encoding and real-time adaptation for advanced Neuro MRI applications – ERATRANIRMA
Medical imaging plays a continuously increasing role in diagnosis or therapeutic follow up of multiple pathologies. Magnetic Resonance Imaging (MRI) in particular is a multi-purpose modality combining unique features. For brain characterisation, it stands as the reference method. With longer avera
Transmission lines and vias on a novel SUbstrate, metallic NAnowire based, for Millimeter-wave Interposer – TSUNAMI
The TSUNAMI project is mainly related to the information, communication and nanotechnologies priority axe of the « Stratégie Nationale de Recherche et d’Information » (SNRI). In particular, this project will develop solutions for future advanced communication systems in the millimeter-wave (mmW) fre
Heart lipotoxicity gene therapy – LIPOCONTROL
Lipotoxicity can be manifested as cardiomyopathy, myopathy, fatty liver... A cascade of events drive cells accumulate lipids and lipotoxic byproducts leading to apoptosis, loss of cardiac myoblasts and cardiomyopathy, mimicking the metabolic phenotype of the diabetic heart. The possible control of
The first phase of this project is to experimentally validate the Ugly duckling concept by analyzing the consistency of the expertise provided by well known international dermatologists for the nevus of one hundred patients. An automatic diagnosis system based on the ugly duckling concept will be bu
«The present research program was designed to generate a series of soluble peptides that specifically eliminate CLL cells, including B-cells with from drug refractory patient). A proof of concept of these peptides will be performed both in vitro and in vivo. To do that, we have gathered a group wit
In a previous work carried out in another laboratory (ASI, USA), various specific and interesting carbon morphologies were obtained by the project coordinator by depositing pyrolytic carbon coatings onto single carbon nanotubes (the “PyC-on-MWCNT” technology). One of these morphologies can be precis
Rep-4-nmCF is the continuation of a drug repurposing programme started 2 years ago by the investigators. It is set to enable the clinical development of an old drug in nonsense mediated genetic diseases. By screening a library of 1200 marketed drugs on a cell model of nonsense mutation defect, they
The main objective of the MM-Scan project is to propose new low cost reconfigurable antenna architectures for automotive radars dedicated to active safety in W band. These architectures are based on multilayer Printed Circuit Board (PCB) technologies known as SIW (Substrate Integrated Waveguide). Th
Improving the treatment of glioblastoma is a public health issue that is the subject of much research, as evidenced by the numerous clinical studies that are open around the world, including several in France. Indeed, the reference clinical protocol, combining external radiotherapy and chemotherapy
Toxoplasmosis is a parasitic disease affecting up to 50% of the human population in western europe. Human is contaminated by eating infected meat. Deleting the animal reservoir will lead to decrease the prevalence of the disease and increase the production of meat livestock, by limiting spontaneous
Within a cloud distributed storage infrastructure, data availability is critical where the repartition mode plays an important role. In this project, we promote the forward error correcting codes usage (most precisely erasure coding usage) targeting to produce redundant fragments to prevent data fra
One third of global food production and 75 % of plant species are dependent on bees. But the honeybee is victim of a massive global extinction. It seems that this decline is multifactorial. The researchers involved in the project have shown a deadly cocktail effect to bees of an association between
Complex Programmable Power Converter Device – ProCD
Power electronics is of great concerns with respect to electrical energy management from optimal production to efficient use. It is intended to improve our use of the electrical energy through a wide spread in many applications. To overcome the corresponding constraints, power electronics moves towa
Current MRI techniques allow to infer information relating to the brain microstructure (axon diameters, neuron sizes). The objective is to offer an industrial a software and hardware architecture connected to the MRI that can make this measure during the acquisition so that the doctor has the resul
Head Injury Prediction Tool – SUFEHM_13
The main objective is to improve the curenbt stage of head modelling by implementing unique anisotropic brain constitutive law to mimic the axonal directions and by consolidating head injury criteria through an extensive real world head trauma simulation campaign. For the first time the injury metri
To date there is no valuable method for answering whether or not spermatozoa can be found in the testes of NOA patients. We bet that seminal germ cell markers could help diagnose the status of fertility in azoospermic men. In the very last step of our discovery phase, we have identified 92 germ cell
Nutrition based gene regulation system applicable for gene therapy in human. – NUTRITHERAGENE
The gene regulation system regulated by blood amino acids is controlled by the amino acids availability. It is composed of (i) a DNA vector including two copies of the amino acid response element (AARE) controlling the expression of a gene of interest according to the concentrations of amino acids i
Neuroprotective properties of peptides derived from the Bornavirus X protein – X-protect
Control of cellular apoptosis is a strategy often used by viruses to limit cellular damage. For neurotropic viruses, it is one key element that allows them to persist in the brain and to cope with the limited capacity of renewal of neurons. To achieve this goal, many viruses express proteins able to
MicroRNA Therapeutics in Asthma – MITHRA
The respiratory epithelium protects the body against many inhaled noxious agents (toxic particles or pathogens). The sterility of the airways is obtained for deep part through an efficient mucociliary clearance: Hundreds motile cilia located at the apical surface of multiciliate airway epithelial ce
«Each year, 17 millions people die from cardiovascular diseases, mainly acute myocardial infarction (AMI) and stroke. During AMI, in a variable proportion of patients presenting with ST-segment elevation MI (STEMI), ranging from 5% to 50%, primary percutaneous coronary intervention (PPCI) achieves e
Our project was to develop a strategy to inhibit the toxic effect of the polyQ-hHtt mutant protein. The starting point was the identification of a 23 aa peptide (P42) in the wild Htt protein, able to save different phenotypes induced by polyQ-hHtt mutant protein, in HeLa cells or in the fly. The use
Low-cost disposable organic laser – VECSPRESSO
Organic lasers enable a wide wavelength tunability across the visible spectrum. However, they have not yet found industrial applications because of two major flaws: they suffer from rapid degradation under illumination, and the pumping source has still to be another solid-state laser with a high cos
CloudPower : a Cloud service providing High Performance Computing to SMEs – CloudPower
High performance computing (HPC) allows scientists and industries to run large numerical application on huge data volumes. The HPC is a key factor in knowledge and innovation in many fields of industry and service, with high economic and social issues: aerospace, finance and business intelligence, e
Efficacy of non-toxic optimized tPA mutants in the treatment of sub retinal hemorrhages. – OptiLYSE
The macular degeneration (AMD) is the first visual acuity loss in the elderly in industrialized countries. Photoreceptors are then damaged following these hemorrhages, leading to irreversible vision loss. In this project, we propose the use an optimized mutant of a fibrinolytic agent (tPA), to effec
Quantum Key Distribution allows two distant users connected by an optical fiber and implementing a well-defined protocol to agree on a cryptographic key with absolute secrecy, guaranteed by the laws of quantum mechanics. QKD has considerably progressed over the past 20 years and has reached a level
Scale-Up of [Ti8O12(H2O)24]Cl8, HCl, 7H2O] – Nano-OxTi
Industrial development of hybrid and OPV cells requires total control over all components of the production chain. This means integrating the preparation of materials, the formulation of colloidal solutions adapted to printing process, assembling devices and their encapsulation. The insertion of met
Development of method and instrument for quantitative assessment of liver steatosis – STEAQUANT
Liver transplantation (LT) is the only available treatment for patients with fulminant hepatitis or end-stage intractable liver failure and the best treatment for cirrhotic patients with HCC. The main concern in liver transplantation is the graft shortage leading to the use of marginal livers. The m
Priam aims to the development of a new intensifed photrobioreactor technology for photosynthetic microorganisms (microalgae) cultivation. The chosen design will incorporate the latest innovations and know-how developed in the field (some of which have been the subject of recent patents) to develop a
Development of new contrast agents for ultrasound molecular imaging of cardiovascular diseases – MicroSound
With the ageing of the population, the prevalence of atherothrombosis will ineluctably increase in the next years and it is anticipated that 18 million people will die of atherothrombotic events in 2030. The medical markets of contrast agents for medical imaging are estimated to 6.2 billions € in 20
Genomic Assembly Tool Box – GATB
The Genome Assembly & Analysis Tool Box aims to provide an easy way to develop efficient and fast NGS tools. The GATB project has been designed as a C++ library of high level functions that benefit from recent advance researches in NGS data structures. The GATB software environment offers: 1 -
- Verify the textile structures the most adapted to generate the appropriate light with optimal homogeneity on the treated skin area, - Evaluate the therapeutical efficiency of the PDT with lightweight and flexible fabric on AK following two different procedures. The textile structure will be opt
Preclinical evaluation of first-in-class modulators of TREK channels, a new target for the treatment of pain. – TREK-ANALGESIA
Chronic pain affects, in Europe, one in five adults. Despite a large therapeutic arsenal, over 60% of patients feel that their pain is not adequately controlled. Treatment with morphine, a ladder 3 analgesic, is often accompanied by side effects (constipation, nausea, vomiting, respiratory depres
A new tool to deliver epigenetic targeted therapeutics in Multiple Myeloma. – ETTMM (Epigenetic Targeted Treatment of
Multiple Myeloma (MM) is a still lethal disease in 2012 characterized by the accumulation in the bone marrow of a clone of malignant plasma cells (MMC for multiple myeloma cells). High dose chemotherapy (HDC) and hematopoietic stem cell (HSC) transplantation, in association with novel drugs as prote
Today, therapeutic proteins or proteins for R&D studies are mainly produced using recombinant techniques. Protein total chemical synthesis is emerging as an interesting complement and potential alternative to the use of living systems for producing small proteins. Importantly, chemical synthesis all
Characterization and production of biosurfactants from Bacillus thuringiensis – Bt-Surf
Companies involved in plant protection or in the food industry are searching for new molecules with foaming and emulsifying properties and more environmentally friendly . The development of this type of susbtances is a main line of research for reducing the use of chemical surfactants. This project
In-situ real-time kinematic viscosity measure on fluid flow without calibration – VISCOFLOW
The problem associated with this new technology, developed to enable the in situ measure of the viscosity, is to be able to shear the fluid at very low to very big rates without destabilizing it. For example, the risk of a too strong excitement of a cream is to see the emulsion collapsing. It is nev
Titanium alloys elaboration with superelastic properties for cladding tests implants – ELASTICITE
The world market of the implantable medical device, in particular of the dental, Maxillofacial, articular prosthesis, and related equipment is strong annual growth. It is the result of better control of the surgical Act. At the same time, in this context, the ageing of the population of European
The serine/threonine phosphatase PP2A is involved in several cellular processes, including apoptosis. We have shown a direct interaction between caspase-9 and PP2A and developed a cell penetrating peptide (DPT-C9h) that specifically blocks this protein/protein interaction. We have clearly demonstrat
Transcatheter Textile Heart Valve – PROVATEX
Non invasive aortic valve implantation has become an alternative technique to surgical valve replacement in patients with high risk for open chest surgery. With over 100 000 procedures already performed clinically, the technology is expected to be extended to less critical patients in a coming futur
Inhibitory Peptides targeting FAS-apoptotic pathways for the treatment of ischemia-reperfusion injuries – PepFAS
The invention concerns the development of a therapeutic tool to treat acute myocardial infarction, a leading cause of world-wide cardioavascular mortality. Beside reperfusion by thrombolysis or angioplasty, which is nowadays the only recommended treatment, there is no efficient therapeutics for repe
Very recently the government following the public debate has defined a politic for the eco-development of products containing nanomaterials. If the purpose is centred on the ecotoxicity and toxicity, metrology and formation, the development of techniques and products limiting the exposure of workers
To date, there is no efficient and specific treatment against oomycetes and oomycete control relies on the use of highly toxic drugs affecting a wide range of pathogenic as well as nonpathogenic organisms. We identified a biomolecule that could be both efficient against oomycete infections and envir
Cirrhosis affects between 130'000 and 214'000 persons in France. Portal hypertension is a frequent consequence of cirrhosis, and strongly contributes to the main complications of cirrhosis. Hepatic venous pressure gradient is an accurate way of measuring portal pressure in patients with cirrhosis bu
It is feared that antibiotics might rapidly be insufficient against plague and no vaccine is available at present. Plague is a potential bioterrosist weapon and has been classified as 'Tier 1' by US CDC. Monoclonal antibodies are more and more used to treat different medical conditions: oncology, a
Therapeutics-21 is dedicated to the development of therapeutic molecules aimed at improving cognitive functions in individuals with Down syndrome. The presence of an extra chromosome 21 leads, among other things, to learning and memory deficits that vary between individuals. Currently, medical and p
Thermochromic ink – Th INK
The project Th INK (on 24 momths) concerns the development of an ink-based thermochromic pigment, with a prototype. The project manager Th INK is the Institute of Condensed Matter Chemistry of Bordeaux (ICMCB, UPR 9048), which possesses a know-how around the thermochromic pigment, associated with th
Atomic Force Microscope (AFM) is now a common tool for material analysis in both academic and industrial areas because it enables non-destructive high resolution images at the nanoscale. However, the available sensors face strong limitations in liquids, making the use of AFM on living material like
Advanced epiready template on silicon for low-defect-density GaN thin film – EASY-GaN
The EASY-GaN project proposes to develop an advanced epiready substrate to produce thin ( < 2 micromètre), high-quality (threading dislocation density < 5x10E8 cm-2) GaN layers on silicon substrates. This product allows addressing the challenging issue of fabricating low-cost GaN-based LEDs on sili