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Concrete is the most widely used building material in the world for its availability, durability and mechanical strength. Nevertheless, we do not have a fundamental understanding of the early age formation of a network of cement particles, and of the evolution of their mechanical properties when tim

Wider research context: Large-scale scientific bottom trawl surveys are still the method of choice to investigate fish-stock densities in marine systems, despite their negative impacts on the environment. The analysis of eDNA, which is becoming a common biomonitoring tool in many aquatic habitats an

Transition from fossil resources to renewable feedstocks is accompanied by re-design of the existing product value chains. Isomerization of D-glucose into D-fructose remains the focus of intensive research in the recent years. Dehydration of D-fructose into 5-(hydroxymethyl)furfural, a promising pla

1) Wider research context/theoretical framework In minimal change disease (MCD), a relapsing-remitting glomerular disease with significant impact on health-related quality of life, glucocorticoids remain the cornerstone of initial treatment. The OBELIX-NEPHROSIS trial will test whether obinutuzumab

Theoretical Framework: The genomes of all living organisms contain transposable elements (TEs) that replicate selfishly for increasing their copy number, thereby with the potential to affect host fitness. Although TEs can reach more than 50% of the host genome, most of them are silenced by different

This project focuses on investigating the molecular mechanisms of the regulation of blood pH, which is a fundamental homeostatic function of the human body, also called "systemic acid-base balance". Even small deviations from the blood's normal pH are life-threatening or even fatal. The kidneys play

This project aims to bring together ferroelectricity and topology to create a new class of material named Ferroelectric Topological Insulators (FerroTis). They will be launched and developped using the narrow gap IV-VI semiconductors and employed for the manipulation of Weyl fermions. The IV-VI m

Arum maculatum (Araceae) has long fascinated due to its foetid scent and deceptive pollination via chemical imitation of brood-sites (putatively dung and other degrading organic matter), its thermogenic activity, and its temporary trapping of fly pollinators (mainly midges such as Psychoda phalaenoi

Wider Research Context / Theoretical Framework: Mechanical and thermal conditioning processes have been used for centuries by the humankind to produce materials with the desired properties. Of particular interest is the application of this ideas to amorphous materials, such as glasses. Amorphous ma

Wider research content: Osteoporosis is a common metabolic disease, causing high morbidity and major economic costs. Obesity is often linked to bone deterioration leading to a greater risk of peripheral fragility fractures and clinical complications in these patients. The association between obesity

Wider research context Primary Sjögren's Syndrome (pSS) is a systemic autoimmune disease often misdiagnosed or overlooked leading to a significant delay of diagnosis. Therefore, most of the current knowledge on the pathophysiology of pSS is derived from patients with long-standing disease. Patie

Wider research context / theoretical framework B cells are critical to the pathophysiology of autoimmune diseases. Their depletion in the chronic autoimmune disease multiple sclerosis (MS) provides clinical benefit both at the relapsing and progressive stages. In the brain of MS patients, B cells

Sensory systems maturation relies on the electric activity in neurons during developmental stages. In the cochlea, the sensory cells, the inner hair cells, fire spontaneous calcium action potentials. This spiking activity at the pre-hearing stage allows the inner hair cells to automatically stimula

Wider research context: Intracellular and extracellular vesicles (IVs and EVs) are highly heterogeneous organelles with fundamental roles in cellular homeostasis and malignant transformation. Deregulation of vesicle biogenesis and release is described to be a feature of transformation and disease p

Wider research context: Hearing loss is pervasive and significantly impacts daily life. Untreated hearing loss in middle age is recognized as the “largest modifiable risk factor“ for dementia. Thus, accurately quantifying hearing damage is crucial, and the Pure Tone Audiogram (PTA) remains the gold

Wider research context The design of high-performance materials requires combining often mutually exclusive properties, such as high yield strength and ductility. Metallic Glasses (MGs) with amorphous structure have high strength, but usually poor ductility with catastrophic failure due to the fo

1) Wider research context / theoretical framework This project aims at the development of a novel framework for high-order discretization of partial differential equations on general domains. The latter pose challenges related to their topology and in particular at the vicinity of, so called, extr

Wider research context / theoretical framework: One of the challenges in the field of molecular magnetism is to make single-molecule magnets (SMMs) practically controllable and accessible. The proposed project aims at controlled and addressable molecular magnetism by confining SMMs into 1D nanost

1) Wider Research Context / Theoretical Framework: Navigating the challenges posed by wave scattering in complex systems is crucial for numerous daily applications, spanning wireless communication, sound transmission, environmental sensing and imaging. In the META-INCOME project, we aim to make sign

Wider research context: The adaptor protein STAC3 is essential for skeletal muscle excitation-contraction coupling and establishes two distinct interactions with the voltage sensor of EC coupling CaV1.1. A missense mutation in STAC3, W284S, disrupts one of the interactions with CaV1.1 and causes STA