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Since the last two decades, use of silicone implants have expanded significantly especially in the field of plastic surgery. Most silicone implants are composed of a solid cross-linked silicone elastomer shell and a liquid gel filling containing a mixture of low-molecular-weight silicone fluids. Reg

Early small-sized blood vessel dysfunctions are increasingly recognized to contribute to the initial stages of many neurodegenerative diseases such as Alzheier's disease or vasculara dementia, long before cognitive impairments appear and conventional markers (Amyloid ß, P-tau). These include Alzheim

Physiological processes and chronic disorders often imply multi-organ crosstalk. Disease modelling and novel therapies (drugs, stem cells) currently require: (i) animal studies, in a context of their reduction by the EU and with limited applicability to humans; (ii) and costly clinical trials withou

We will develop and use innovative holographic laser imaging, detection, and ranging (LIDAR) instruments and software for ophthalmology. These non-invasive methods will allow reliable measurements of biomarkers such as blood flow, arterial wall stiffness and local neuronal activity in the eye. These

In this proposal, the main objective is to optimize Chemical Exchange Saturation Transfer (CEST) magnetic resonance imaging (MRI) for pH mapping on a 3-T clinical scanner in skeletal leg muscle of patients with neuromuscular disorders. Using MR spectroscopy (MRS), we have shown the interest of ass

Ocular drug delivery systems (DDS) to target the retina evolve rapidly, however effective pharmaceutical treatments to directly block optic nerve degeneration in glaucoma are not available. Intravitreal injection of API-loaded microparticles represent a promising strategy to improve long-term effica

Cancer is the leading cause of mortality and morbidity globally. Radiation therapy is used in more than 50% of patients treated for cancer. Head and neck tumors have the sixth most frequent cancer prevalence and are often associated with poor outcomes and lifelong sequels. Radiation therapy is parti

Neurodegenerative diseases, such as Alzheimer’s disease, represent a major public health challenge due to their increasing prevalence and the lack of effective curative treatments. Early diagnosis is now widely recognized as essential to improve patient care and to support the development of new the

Dynamic translaryngeal ultrasound (dTLUS), a non-invasive and inexpensive technique, has emerged in recent years as an alternative to nasofibroscopy, a minimally invasive method to assess vocal cord paralysis. This paralysis is the major risk (occurrence of 3 to 5%) associated with cervical surgery

The usual treatments of infectious diseases with antibiotics are facing more and more frequent failures due to the dissemination of antibiotic resistance. In this context, phage therapy, or the therapeutic use of bacterial viruses, called bacteriophages or phages, to fight infections caused by antib

Recently, we paid attention to a physical phenomenon called Gouy phase shift - ? phase change that waves experience, when they pass through an optical focus. We found that this effect can be used to create a new type of optical imaging system that works in transmission and captures optical sections

Expected results include significant reductions in tissue damage, oxidative stress, and inflammation through the combined use of NPV and dynamic graft mobilization. These advancements are anticipated to maintain the functional integrity of the lungs during EVLP and improve the quality of grafts for

Stroke survivors often suffer manual dexterity impairments reducing their autonomy and quality of life. Recovery of dexterity is drastically suboptimal and the degree of recovery is difficult to predict. Existing therapies aim at restoring upper limb movements, but fail to target manual dexterity mo

Stroke is one of the main causes of chronic disability in the world. Patients recover spontaneously, but most often retain after-effects that can be reduced by rapid implementation of appropriate rehabilitation. Optimizing rehabilitation to maximize autonomy is therefore a major public health issue.

The Central Nervous System (CNS) is a therapeutic target for many brain disorders including Amyotrophic Lateral Sclerosis (ALS) that is the focus of our project. Although a leakiness of the blood-brain barrier (BBB) is admitted during the progress of some brain pathologies, crossing the BBB remains

Malaria elimination and eradication will be difficult to reach since evidence exits that asymptomatic carriers are an important reservoir of circulating malaria parasites in the population. Malaria elimination, once obtained in a country, will require a surveillance system and continued measures tha

Medical implants replace dysfunctional or missing body parts to maintain physiological functions. The associated market is growing by 4%/year. However, the key factor restraining the market is high implant costs. In this view, PEEK and CRF-PEEK due to biocompatibility, mechanical properties similar

Magnetic Resonance Elastography (MRE) is a non-invasive clinical tool for liver fibrosis characterization, yielding tissue stiffness values maps correlated to fibrosis stages. In the case of short T2 relaxation occurring in hemochromatosis, conventional MRE with its longer echo-time fails to deliver

The ImAgGa project consists in developing a new gallium-68 radiotracer highly specific to articular cartilage proteoglycan aggrecan. This new complex will allow early diagnosis and quantification of osteoarthritis as well as its longitudinal follow-up by PET imaging. Such a tool is essential for the

The objective of the project is to simulate in real time the deployment of metallic stents in coronary arteries during catheterization, using patient-specific data extracted from intraoperative images. The aim of the simulation is to avoid under-deployment or over-deployment which are respectively a

The main goal of this project is to harness the latest advances on machine learning-based neuroimage processing technologies to improve function-preserving brain tumour resection. Identifying eloquent brain regions is fundamental to performing tumour resection while preserving a maximum level of cog

Therapeutic ultrasound offers great perspectives for minimally-invasive surgery, enhanced drug delivery or cancer immunotherapy. A number of emerging applications rely on ultrasound cavitation, which is the oscillation of ultrasound-induced microbubbles,. In any of these applications, a volumic moni

Vectorized radiotherapies using alpha radionuclides (e.g. At211) are strongly developing as they allow to overcome hypoxic tumors radio-resistance on metastatic cancers. But, conventional gamma imaging methods (SPECT & PET) don’t allow to get a good image of dose deposition for those therapies. This

The main objective of this highly interdisciplinary and collaborative project is to demonstrate that innovative optically pumped magnetometers (OPM) using helium-4 (4HeOPM) can overcome the limitations of SQUID and alkali OPM sensors to monitor brain activity in epileptic patients including children

The BCI4IA project aims to design a brain-computer interface for detecting intraoperative awareness during general anesthesia (GA). No satisfactory solution exists when this phenomenon causes severe post-traumatic stress disorder. The first reaction of patients is to move, but the curarization used

Lung immaturity at birth in preterm newborns (respiratory distress syndrome or RDS) requires the exogenous surfactant administration shortly after birth. Current surfactant administration techniques, although described as "less" invasive (Less Invasive Surfactant Administration or LISA), still requi

In recent decades, there has been a tremendous increase in the spatial resolution of array sensors, which can now exceed 100 megapixels at low cost, and which has revolutionized biomedical imaging. As spatial resolution has become less and less of an issue, the spectral imaging capabilities have rem

The aim of this interdisciplinary project is to adapt advanced laser technologies for applications in the field of life electronics and health. The complexity of certain organs constitutes, for biologists, a major obstacle to deciphering their functioning and better understanding certain pathologi

Bioprinting-assisted disease modeling is an exciting new avenue of research. It holds the promise of new alternatives to animal models for faster, wider and more ethical biological investigations and drug screening. As such, it also offers new perspectives for the identification of therapeutic targe

Falls in the elderly pose a major health, social and economic problem. These falls occur mostly during activities of daily living, and mostly during walking. In this context, the e-WALKING project aims at proposing a new approach to improve the balance performance of elderly people during walking, i

In circulatory disorders, impaired deformability and aggregation of red blood cells (RBCs) are frequent findings, which contribute to alterations in macro- and micro-circulatory blood flow. Such disorders may affect tissue perfusion and result in functional deteriorations. For instance, in sickle ce

We propose a new concept of coating, free of bactericidal agent, intended to control bacterial biofilms, responsible for infections of biomaterials and biomedical devices. The approach is based on the fact (i) that certain mechanical surface characteristics of the materials are detrimental to the ad

Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting 340,000 women in France. The objectives of the INORA project are (i) to predict in a patient-specific manner the mechanical state of the internal structures of the foot (ex: joint pressures) and (ii) open the way to in-silico clin

The recovery of a correct dynamic balance is at the heart of gait rehabilitation. However, no real consensus exists about an indicator that could be used to monitor the balance during walking either for humans or humanoid robots that share similar issue in this context. The ambition of the project i

Liposomes have been the most successful type of nanomedicine for cancer patients, playing a leading role in improving the tolerability of chemotherapeutics. However, to advance the success of liposomal drug delivery and cancer treatment, new approaches to physically trigger drug release in cancer ti

Atrial cardiomyopathy has been defined as any electrical and/or mechanical dysfunction of the left atrium. This dysfunction can lead to Atrial Fibrillation (AF), which is responsible for a third of all ischemic strokes. However, atrial fibrillation is not the only left atrium-related cause of stroke