Search

A failure to repair or regenerate tissue can result in devastating degenerative diseases. Impaired skeletal muscle repair leading to accelerated muscle loss is observed in Duchenne Muscular Dystrophy (DMD), one of the most common genetic diseases in man. There is currently no cure for DMD patients.

Landslides represent one of the costliest geo-hazards and a growing threat to human life across the globe as a result of climate change and population growth. Although landslides are hard to observe directly, their signature is available in the form of the seismic, aeroacoustic, hydroacoustic, and t

Until recently, most of the major advances in machine learning and decision making have focused on a centralized paradigm in which data are aggregated at a central location to train models and/or decide on actions. This paradigm faces serious flaws in many real world cases. In particular, centralize

The construction sector is responsible for 39% of energy and process related CO2 emissions in 2018 and no other industry in the world uses more materials by weight and more embodied energy. Earth construction has the potential to offer significant advantages over conventional techniques in terms of

Our project focuses on the regulatory properties of a subset of microbiota-specific TR1-like regulatory T (Treg) cells, for which we have already shown an unprecedented association with the clinical outcome of patients in various inflammatory diseases, for a therapeutic use in inflammatory bowel dis

Liver transplantation (LT) is a life-saving procedure for end-stage liver diseases, notably decompensated cirrhosis (DC) and hepato-cellular carcinoma (HCC). Its efficacy is yet hampered by the risk of death/drop-out on the Wait List (WL). This risk is driven by organ shortage and is mitigated by or

Obesity rates in late teens has increased in Europe from 6% in 1980 to 32%, with long-lasting effects on the prevalence of severe obesity, early onset diabetes and cardiovascular disease, premature death and disability. Efficiently fighting adult obesity is difficult but prevention and treatment of

Type 1 diabetes (T1D) is an incurable disease, often starting in childhood, with a risk of devastating complications, premature mortality, and high social burden. It is caused by the autoimmune destruction of insulin-producing beta cells, yet the standard of care is insulin replacement, acting only

Regulatory T cells (Tregs) are important therapeutic targets for many immunopathologies. Stimulating Tregs with interleukin-2 (IL-2), the key cytokine supporting Treg fitness, is being actively developed, but is likely to be insufficient to achieve optimal therapeutic efficacy in severe diseases. Th

Two thirds of the five million European children with asthma experience frequent asthma attacks resulting in decreased quality of life. The lack of a personalised management strategy for asthma prevents paediatricians from providing optimal care. The objective of the TWIN4KIDS project is to use a d

As major players in the regulation of immune responses, regulatory T cells (Tregs) are important therapeutic targets for autoimmune and inflammatory diseases. Interleukin-2 (IL-2) used at low doses (IL-2LD) stimulate and expand Tregs in vivo. While 1st-generation native IL-2LD are currently under ex