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Acquire digiTal biomarkErs in infanCy witH sensorized TOYS for early detection and monitoring of neurodevelopmental disorders – TECH-TOYS
Neurodevelopmental disorders (NDDs) are a group of frequent (1/10 children) sensori-motor, cognitive, communication, learning, behavioural disorders of multifactorial aetiology, with onset early in life but lifelong consequences. Despite advances in our understanding of aetiology, diagnosis and star
Early and accurate diagnostic and prognostic markers for Alzheimer’s disease – EDAP-AD
Alzheimer’s disease (AD) has a major impact on daily functioning and quality of life and is characterized by a huge socio-economic burden, with at least 50 million persons affected worldwide. There is currently no disease modifying treatment, which can be attributed to important knowledge gaps. For
Algorithm of Graft Outcome in Renal Allotransplantation – AGORA
In renal transplantation, monitoring the risk of subclinical rejection (SCR) and graft failure remains challenging. AGORA partners developed and validated 1-year non-invasive biomarkers allowing the prediction of patients at high/low risk of subclinical rejection and graft failure: 1) the cSOT gene
Epigenomic and machine learning models to predict pancreatic cancer: development of a new algorithm to integrate clinical, omics, DNA methylation biomarkers and environmental data for early detection of pancreatic cancer in high-risk individuals. – IMAGene
Pancreatic cancer (PC) has the lowest survival rate of all cancers in Europe, with no early detection strategies available. The IMAGene project will develop, implement and test a comprehensive Cancer Risk Prediction Algorithm (CRPA) to predict PC in high-risk (HR) asymptomatic subjects; it will inve
A Machine learning approach to Identify patients with Resected non-small-cell lung cAnCer with high risk of reLapsE – MIRACLE
Early-stage non small cell lung cancer (ES-NSCLC) represents 20-30% of all NSCLC and is characterized by a high survival rate after surgery. However, there is variability in clinical outcomes among patients sharing the same disease stage, suggesting that other factors could determine the risk of rel
Behaviours in REM sleep: personalised Automatic 3D Video Analysis as novel tool to detect alpha-synucleinopathies – BRAVA
Rapid eye movement (REM) sleep behaviour disorder (RBD) is characterized by abnormal muscular activity and dream enactment in REM sleep. In its isolated form (iRBD), it is recognized as an early alpha- h Lewy bodies and multiple system atrophy). Due to the low number of specialized sleep centres and
International - Rapid rEcognition of CORticosteroiDs sensitivity or resistance in Sepsis – i-RECORDS
Sepsis and COVID-19 are both placing a major burden on societies and populations worldwide. Deregulated host response to infection is the hallmark supporting the routine use of corticosteroids (CS), a low-cost and highly efficient class of immuno-modulators, in sepsis/COVID-19. Stratifying patients
