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ImagiNg carrier DynamIcs at the nANoscAle thanks to light- and electron-matter interactions – INDIANA
This new correlative technique will be used to explore three research directions. We will first estimate micro-LEDs efficiency at the nanoscale. Then, by exciting simultaneously an LED with an electron beam and a below band gap excitation laser, we will investigate the influence of point defects on
ultra-High-spEed high-Resolution force Microscopy and spEctroscopy of biological Systems – HERMES
HERMES wants to take high-speed atomic force spectroscopy and microscopy (AFM) to the next level, opening a new experimental window in molecular biophysics experiments. We will develop nanosecond atomic force tracking in liquids and ultra-high-speed force imaging, with a spatial and force resolution
Spectrumless near-field thermal radiation sensor for nanomaterial characterization – STORE
The goal of the STORE project is to develop a new characterization technique for materials and nanostructures at the intersection between atomic force microscopy (AFM) and the flourishing domain of near-field radiative heat transfer. AFM approach curves, when the tip is moved towards the contact wit
Bio-sensing using nanocrystal lasing in whispering gallery mode microcavities – Nanowhispers
Biomolecular detection using energy transfer between a donor and an acceptor located on a pair of antibodies is a one-step, no-wash, method that is simple to implement. It remains however inefficient because it is limited to donor-acceptor separation distances of a few nm, while antibody-antigen com
Acoustic droplet generation and opto-mechanical nano-resonators mass spectrometry for fast analysis of viral particles. – AERONEMS
Viruses are biological entities that infect all life forms. They occur in a broad variety of samples, and their small size (
Nano-functionalised photonic fibre probes for next generation Bio-Chemical sensors – FUNSENS
The growing demand for reliable and robust methodology in biochemical sensing calls for continuous development and advancement of sensor technologies. The most demanding criteria for a biosensor are that it should have tremendously high sensitivity and reliability to detect biomarkers of diseases at
Planar Reconfigurable Optics For Imaging Technologies – PROFIT
Background – In the current era of images, integrated reconfigurable optical elements are essential building blocks to improve the performance of new photonic devices, all the way from the consumer market, with displays and cameras, to the research and clinic environments with advanced microscopy. T
Microfluidic manipulation of coccolithophore microalgae for in vivo biomineralization studies: impact of ocean acidification conditions on calcium carbonate formation – MICROCOCCO
Coccolithophore microalgae (CM) are one of largest producers of CaCO3 (coccolith shells) in our oceans. They are involved in several major biogeochemical cycles and are one of the main drivers of the global carbon pump that removes atmospheric CO2. The threat of ocean acidification (OA) has generate
Characterization of the radiation of the human voice: from vocal tract to far field – RAYOVOX
Human communication relies primarily on acoustic propagation and radiation to achieve the transmission of information. The radiation of waves at the lips remains a poorly understood phenomenon, although it affects a large number of everyday situations. This project proposes the development of an mul
5D super-resolution microscopy for nanoscale biology – 5D-SURE
Super-resolution (SR) microscopy is a revolution that allows us to revisit biology at the nanoscale. Among SR strategies, Single Molecule Localization Microscopies (SMLM) offers the highest spatial resolution (~20-nm) for fixed cell imaging whereas Structured Illumination Microscopy methods (SIM and
Smart MEMS Instrumentation for Biophysical flow Cytometry with Statistical Learning – CYTOMEMS
The objective of CYTOMEMS is to demonstrate the first smart MEMS equipment performing high content biophysical characterization of cells in flow for their classification by statistical learning. Cell characterization is carried out by a bioMEMS device incorporating a microchannel for the passage
Focused Ion beam by correlated electron feedback – FIBback
This research project aims to achieve the sub-nanometric regime for imaging and focusing of ion beams. In order to properly control the characteristics of these ion beams (coherence, aberration, energy, dispersion, etc.) we propose to take advantage of the correlation between each electron/ion pair,
Electro optic dual comb spectroscopy for mid-infrared applications – ELECTROCOMB
The ELECTROCOMB project aims at the generation of wavelength-flexible frequency combs in the mid-infrared spectral range as a powerful tool for dual-comb spectroscopy (DCS) based on comb generation with electro-optical modulation of a continuous-wave laser. This technique has many advantages but is
High Kinetic Energy Atom Probe : A 3D Nano-analytic microscope with molecular and kinetic energy discrimination – Hi-KEAP
The energy discrimination of ions received on the atom probe position sensitive detector is considered as the Holy Grail in the development of this nanoanalysis technique. Indeed, the use of kinetic energy information must make it possible to remove the degenerations induced by interferences in mass
Extended machine vision control capabilities using digital holography & artificial neural networks – HOLO-CONTROL
HOLO-CONTROL aims to explore multiscale sensitivity in the positioning of samples versus the six degrees of freedom (DoF) by digital holography to perform sub-voxel measurements in real-time. A key novelty of the project will be the incorporation of Artificial Intelligence (AI) harnessing Artificial
THz dynamics in MUltiFerroIc Nanostructures and Superlattices – THz-MUFINS
To meet these challenges, we need to establish a comprehensive description of ultra-fast opto-acoustic and acousto-optic processes in multiferroic nanostructures and superlattices. The opto-acoustic process consists in generating acoustic waves with ultra-short light pulses (femtosecond laser) while
Terahertz ATR Sensor for real-time study of cell membrane permeabilization – TeraCellATR
Methods to monitor in real time the molecular exchanges across the membrane of living cells are still rare. Benefiting from recent technological developments, the terahertz domain of the electromagnetic spectrum offers significant potential in the biomedical field. Our project, based on a close two
2D and 3D electrical tomography: Corrosion diagnosis of reinforced cement-based materials – EL-TORO
EL-TORO aims at developing a novel reliable and modular multi-electrodes device for the non-destructive monitoring and diagnosis of Reinforced Cement-based (RC) structures. The device will provide 2D/3D images of both the electrical resistivity of the cement-based materials (?, in O.m) and the polar
Electron Holography Imaging of Spin waves – EHIS
The goal of the EHIS project is to use, for the first time, Electron Holography as a new experimental tool for spin dynamics mapping in an individual nanostructure. The principle of the method relies on the modification of the magnetic phase images due to the quasi-static components of the magnetiza
Coherent All-Optical Analog Pulse Compression Lidar – COCOA
The COCOA (Coherent All-Optical Analog Pulse Compression Lidar) project aims to develop a new coherent lidar system based on frequency shifting loops. This architecture combines optimal performance (range, resolution, security) with great simplicity by overcoming the need for fast electronics, both
e-Substrates for molecular imaging in cells – NIS
Based on the use of evanescent waves, total reflection fluorescence microscopy (TIRF-M) allows observing events occurring at the interface between the microscope coverslip and the biological sample. In the cell, this interface corresponds to the plasma membrane, where many processes such as endo/exo
Amplified biosensors for metabolites based on fluorescent nanoantennas – AmpliSens
Detection of metabolites in biological fluids and their profiling at the point of care enable early diagnostics of diseases. However, current fluorescence assays are limited by the modest specificity to small organic molecules and insufficient brightness of fluorescent molecular probes. To address t
Holographic Ultrasound Laser Optical Tomography – HULOT
Optical imaging of small objects (inferior to mm) in a highly scattering environment becomes increasingly challenging with imaging depth (cm to meter range). It would lead to disruptive innovations for in-situ characterization, e.g. non-destructive control, turbid media (pollutant detection, …), or
ComputatIonal coherent Raman far-fIeld nanoscopy – COCOhRICO
Life is made of molecular interactions, therefore probing molecules’ interactions at their native size, and in their natural environment, is the Holy Grail in biology. Yet, reaching such a high-level spatial resolution in living biological systems is extremely difficult. Towards that end, a large re
Artificial Intelligence for Atomic resolution and Real-time in situ Transmission Electron Microscopy – ARTEMIA
Many imaging techniques, particularly in environmental transmission electron microscopy (ETEM), generate images with degraded signal-to-noise ratio, contrast and spatio-temporal resolution, which hamper quantification and reliable interpretation of data. Moreover, the extraction of structural inform
Electrochemistry of redox liposome nano-impacts for bacterial toxins sensing – ELIPOX
The scientific objective of ELIPOX is to design redox liposomes mimicking the cell membrane for using the interaction process of the target virulence factor as sensing strategy for pathogenic bacteria. ELIPOX is mainly supported by the coordinator’s previous results on electrochemical single collis
Morphogenetic electromagnetic design – MetaMorph
The computerization of the means of measurement and production are indeed in several aspects based on the development of dedicated electromagnetic components. Whether they allow these systems to communicate, to interrogate their environment or to direct data flows between their various sub-parts, th
ElectrochemiLuminescence nano-Imaging of Single Entities – ELISE
Electrochemiluminescence (ECL) is the light emitted by the excited state of a luminophore upon an initial electrochemical reaction. It is a hybrid technique combining orthogonal modalities, in which electrochemical stimulation is coupled to optical detection. ECL is a powerful analytical technique,
Spectrally tunable ADVANced nanosource for local SPECtroscopy – ADVANSPEC
Fast growth of Nanophotonics requires development of advanced integrated light nanosources for, e.g., nanospectroscopy and nanosensors. In this context, hybrid plasmonic nanosources (HPN), based on coupling between metal nanostructures and quantum nanoemitters, have given rise to intense research ef
Experimental station for table-top time- and angle-resolved photoelectron spectroscopy – EXPERTISE
Understanding the microscopic mechanisms that drive the laser induced ultrafast spin dynamics (LI-USD) is one of the hottest topic in magnetism. Recent works have evidenced that they depend intimately on the electronic band structure in the laser excited state. Tackling the fundamental processes of
Diffuse Acoustic waves Correlation in Layer-On-Substrate structures – DACLOS
This project paves the way for an original microstructure auscultation technique based on diffuse wave correlation (DWC). The objective is the non-destructive testing and evaluation (NDT&E) of Layer-On-Substrate (LOS) specimens. Currently, one possibility to inspect these structures consists in usin
Development of low-dose cryo-scanning transmission electron tomography using sparse images to study whole eukaryotic cells at the nanometre scale – C-STET-4-E-Cells
The project C-STET-4-E-Cells aims to develop an original cryo-scanning transmission electron tomography (cryo-STET) imaging method using sparse images for low dose applications in biology. The goal is to propose to the structural biology community a new imaging method to study in 3D large complexes