Search

Insecticide-based vector control has been recognised as the principal contributor of the malaria-incidence reduction since 2000. Recently, this trend has worryingly stalled or even reversed in some countries. One identified reason of such stall is the evolution of insecticide resistances to the wide

Hosts are usually infected by multiple parasites simultaneously. These parasites can be in conflict or benefit from the presence of each other. In this project, we wish to investigate the consequences of the infection by an intestinal nematode with immunosuppressive effects, on the infection dynamic

Bacteria have evolved a highly conserved chromosomally encoded recombination machinery, Xer, to resolve chromosome dimers. With the exception of a few species, Xer is composed of two tyrosine recombinases, XerC and XerD, which act on a specific chromosome site, dif. Diverse mobile elements harness X

Buruli ulcer is one of the 17 neglected tropical infectious diseases in the world. It is caused by the bacteria M. ulcerans and its symptoms are necrotizing cutaneous lesions.Buruli ulcer affects populations with weak access to sanitation, safe water and care living in rural areas of west and centr

Aquaculture has become critical for human food production, and is the fastest growing food production sector. It is threatened by multiple diseases especially those caused by viruses, for which there are no treatment available. The sustainable development of aquaculture therefore requires new vaccin

Because they replicate inside cells and rely for the most part on the host molecular machineries for their replication, viruses have to deal with multiple defense mechanisms based on the recognition of their genome by the cell. This leads to a never-ending arms race in which the pathogen and its hos

Highly Pathogenic Avian Influenza Viruses (HPAIV) evolve from Low Pathogenic viruses (LPAIV) through a process involving nucleotide substitutions and nucleotide insertions in the sequence encoding the viral hemagglutinin (HA), resulting in the apparition of a stretch of basic amino-acids at the HA p

Describing and understanding factors affecting the distribution and transmission of pathogenic agents in wild animal populations is important for basic and applied reasons, notably in the current context of global change and recurrent emergences of infectious diseases, which can be related to human

Diarrheas are responsible for 1.57 million deaths. The highest health burden occurs in Sub-Saharan Africa where 85 million people, living mainly in rural areas, are using surface water for domestic uses, and where bacteria are the 2nd leading cause of diarrhea. Moreover, climate change is expected t

The goal of this project is to study the strategies undertaken by Gram-negative bacteria to respond to sub-lethal antibiotic stress, and particularly the role RNA modifications and translation fidelity and efficiency. Bacteria frequently encounter low antibiotic concentrations in their environments,

Bedbugs feed on blood exclusively during the night. Reactions to bites can be severe, and the psychological impact of bed bugs is significant. Despite their limited ability to actively disperse, bedbugs colonize new areas extremely quickly due to human movement. A resurgence of bedbug infestations h

Plant health is of paramount importance to ensure food supplies for a growing world population. The Potyvirus genus is the most damaging group to crops. The high mutational frequency of these viruses results in an adaptive potential compromising the sustainability of host resistance. Understanding t

To meet the demographic pressure, the livestock industry must intensify production while striving for sustainable management. With the emergence and re-emergence of infectious diseases, improving animal health and welfare is a key aspect of this challenge. Among the most prevalent pathogens is a gro

Fungal diseases have been consistently neglected despite their astonishing impact on human health. There are no effective vaccines available against these diseases and the arsenal of antifungal molecules is restricted to only four classes. Fluconazole (FCZ) is the most commonly used antifungal molec

The ApiNewDrug project is looking for drug alternatives against zoonoses transmitted by two apicomplexan parasites, Toxoplasma and Cryptosporidium, responsible for toxoplasmosis and cryptosporidiosis respectively. These orally transmitted parasites have a significant impact on human and domestic ani

Intracellular bacterial pathogens enter host cells to form a bacterial containing vacuole (BCV). Then, the BCV matures or ruptures leading to two distinct pathogen-dependent intracellular niches; one vacuolar and one cytosolic. The specific intracellular niche is intimately linked with the bacterial

In addition to antibiotic resistance mechanisms, antibiotic tolerance and persistence are a challenge for effective therapy. Tolerance and persistence are non-heritable phenotypes that reduce and compromise antibiotic killing efficacy. Those two phenomena allow for a certain fraction of bacteria to

The fight against malaria faces to the emergence and massive spread in Asia of resistance of the parasite Plasmodium falciparum to the antimalarial drugs artemisinins. Artemisinins are the core component of Artemisinin-based Combination Therapies (ACTs) combining an artemisinin derivative with anoth

Research on P. vivax is greatly lagging behind P. falciparum mainly due to the absence of an efficient laboratory cultivation system on one hand. On the other hand most of the current investigations are compartmentalized, focusing specifically on either individual P. vivax stage (blood stage, liver

Parasitic nematodes infecting humans and animals are major public health problems worldwide. Ivermectin (IVM) anthelmintic is the most widely used antiparasitic drug in veterinary and human medicine; a powerful example of “One-Health” drug. Most grazing ruminants are infected by a variety of helmint

The objectives of the BAoBAb project are to better understand bacterial adaptation strategies to disinfectant biocides used in the food industry, to evaluate the impact of this collective adaptation on the development of resistance to antibiotics and to identify the underlying mechanisms. The role o