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Toxicity to humans of ingested micro and nanoplastics combined to metallic environmental contaminants – PLASTOX
Due to their attractive properties and low cost, plastics are widespread used in daily products. One of their most interesting property is their low degradability, but it becomes a drawback when plastics are released in the environment, because it leads to substantial and long-term accumulation of p
Evaluation and quantification of the impact of Sunscreen Pollution On Coral – SPOC
UV filters are widely used for skin protection against cancer. Their impact on corals was poorly investigated but it was shown that octocrylene and several benzophenone filters exert direct detrimental effects on corals, and that other ingredients in sunscreens and cosmetics exacerbate their toxicit
HydrOThermal Mercury - the natural story of a contaminant – HOT_Hg
The UNEP Minamata Convention aims to reduce human exposure to toxic mercury (Hg). It is believed that anthropogenic Hg emissions have increased surface ocean Hg levels 3-fold since pre-industrial times. The estimated Hg increase requires a thorough understanding of both the anthropogenic and the nat
Side effects of pigments used in tattoo inks on skin cells – Tattooink
One French adult out of 7 now bears at least one tattoo, a proportion peaking to almost 1 out of 4 in young adults (
Validation of a bioaccessibility method for endocrine disruptors in indoor dust – BIOACID
People spend nearly 90% of their time indoors where they are exposed to many pollutants. Among these pollutants, semi-volatile organic compounds (SVOCs) are of particular concern as most of them are suspected to be endocrine disruptors (EDCs) with adverse health effects such as reprotoxic, neurotoxi
Maternal Exposure to Mixed Organics pollutants: placental epigenetic marks and Risk assessment for offspring’s health – MEMORI
The general population, including pregnant women, is exposed to endocrine disruptors, including phthalates and synthetic phenols (PSPs). These compounds are used in a large number of consumer products such as plastics, epoxy resins, cosmetics and food packaging, leading to daily exposure of pregnant
MICromycete tarGeted bIotechnological Valorizations for Environmental bioRemediation – MicGIVER
Since the beginning of the industrial age, humanity has been able to exponentially increase its productivity and access to resources, and this, to levels unimaginable only 200 years ago. If this inexorable technological progress has made it possible to multiply the human population sevenfold in a ce
Marine plastics as vectors of human pathogens – VectoPlastic
Transported by currents, plastics strand on the coastal areas, important places of artisanal fisheries. Plastics can harbor pathogens that are involved in human epidemics. It is thus legitimate to ask whether these pathogens and their virulence & resistance genes (PVR) can be transferred to marine a
Multistress effects on fish pathogen interactions – MULTIPAT
Global changes expose wild populations to increasing pollution and emerging pathogens, which could have complex interactive effects on organism health. However, the ways in which multiple stressors and intraspecific variability scale up to shape health and disease risk remain poorly understood. Base
From Auditory Fatigue to Hearing Disorders? A Translational Study on Daily Noise Exposure. – FATIGAUDIT
The permissible exposure limit in many industrial countries is 85 dB(A) for an 8 hours working day. However, a daily noise exposure at 85 dB(A) is responsible for “auditory fatigue”, a temporary decrease of hearing sensitivity at the end of the day that has been largely ignored so far. When combinin
Understanding and preventing toxic Non-Intentionally Added Substances (NIAS) formation in commonly used plastic parts – NIAS
Thermoplastics polymers are always compounded with additives. These additives, sometimes with interactions with impurities present in the polymer, are reacting during the compounding and processing steps used to produce a material. These unwanted chemical reactions lead to many toxic Non-Intentional
Occurrence and toxicity of legacy and emerging Perfluoroalkyl substances (PFAS) in seabirds: A large-scale survey in overseas and metropolitan France – ToxSeaBird
Poly and perfluoroalkyl substances (PFAS) are surface-active agents used in in a multitude of manufactured products including firefighting foam, waterproof clothing, non-stick cookware, food packaging, personal care products, electronics and metal plating and even pesticides. Transported over long d
Bioprospecting, discovery, mode of action & biosynthesis of marine biotoxins – ICH-NEURO-MET
Phytoplankton lifestyle is characterized by episodic blooms attaining high cell densities and covering large sea surfaces. When dominated by toxin-producing species, harmful algal blooms constitute a potential threat for public health and aquaculture activities resulting in huge annual economic loss
Environmental Dynamics and Impacts of contaminant cocktails originating from Plastics in soil ecosystems – e-DIP
The project addresses the evaluation of significant environmental threats of known and unknown plastic additives, which are added to soils in quantities comparable to those of harmful (agro-)chemicals. The aims of this project are to 1) evaluate the toxicity of the cocktails of contaminants assoc
Mechanisms of environmental metals induced cytoskeletal synaptic toxicity: from super-resolution imaging to molecular identification – SuperResMetalToxSyn
Recent research works have emphasized the consequences of extended low-level exposures to large populations. It is increasing recognized that the onset and progression of many age-related neurological diseases, including Alzheimer’s disease, may be triggered and/or accelerated by environmental expos
Impact of environmental stress on skin integrity and consequences for susceptibility to infection with SARS-CoV-2 – INTEGRSKIN
The outbreak of SARS-CoV-2 has caused the pandemic associated with the severe acute pulmonary disease named COVID-19. Cell entry of virus depends on the availability of virus receptors and entry cofactors on the surface of host cells. These receptors have been shown to be expressed in human skin mak
Trace metal cocktails in birds: physiological and transgenerational effects – TRAMET
Anthropogenic activities generate a stress for wildlife and have negative effects on animals’ health. However, with correlative studies in the wild it is a challenge to disentangle between the effects of different pollutants. Laboratory studies are needed to reveal causal relationships. Yet, for tra
Mercury methylation by microorganisms: from cell to environment – MicroMer
Mercury (Hg) is a global pollutant, able to be converted into highly neurotoxic monomethylmercury (MMHg), a compound bioaccumulated and bioamplified in food webs. Microorganisms regulate environmental MMHg level, by controlling directly inorganic Hg (IHg) methylation and MMHg degradation or indirect
Metal nanoparticles contamination of milk: mother-to-young transfer and role of extracellular vesicles – NanoMilk
The release of metal nanoparticles (NPs) in ecosystems is constantly growing. NPs are massively manufactured for their useful properties such as UV-filter, anti-bacterial agents, remediation agent, fertilizers, or pesticides. Sampling from lakes, rivers, seas and even tap water indicated the prese
Nuclear receptor signaling and endocrine disruption in a mollusk: the power of functional experiments – MusMod4EDC
Pervasive endocrine disrupting chemical (EDC) pollution is both a healthcare challenge and a threat to biodiversity. The impact of EDC pollution on humans, and other vertebrates, has been extensively studied, and numerous pathologies triggered by EDC exposure at different stages of life have been di
Multi-scale mechanistic Analysis of Radionuclide INteractions with marine algaE – MARINE
MARINE is a 42-month project that aims at exploring chemical interactions between radionuclides released in seawater and marine organisms, from a multiscale mechanistic perspective. Seawater is one of the top priority environmental compartment regarding chemical pollutants contamination, including
Deciphering the molecular mechanisms underlying the tolerance and accumulation of metals in a metal-hypertolerant green microalga of the Coelastrella genus – DemoniaCo
Pollution of terrestrial and aquatic ecosystems by trace metal elements, also referred to as heavy metals, is a major and ever-growing threat to environmental and human health. A better understanding of the effects of toxic elements on land plants and microalgae is critical to develop approaches for
Chroco: Chronology of coping with a toxic stress: from omic to apical responses – Chroco
The Chroco project proposes to investigate simultaneously both dimensions of the toxicant exposure, concentration and time, to characterize contamination impacts from omics to apical levels with deepened findings contextualized by exposure intensity and duration. In particular, the project will addr
Integrated biogeochemical, geographical and hydrological approaches to track sources of contaminants in mixed land-use watersheds – CHYPSTER
The presence of numerous chemical and microbiological contaminants in aquatic ecosystems, including toxic (e.g. endocrine disruptors) and/or persistent contaminants can lead to a significant degradation of the ecological status of natural waters and increase human and animal exposures to these conta
Impact of pollutants and AHR signaling on cardiac function in predisposed-models of cardiomyopathy – POPHeart
The interaction of pollutants with cardiac disease has only recently emerged. 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) is the most toxic and persistent organic pollutant that bioaccumulates in the body through the food chain. The toxicity of TCDD is mediated by the activation of Aryl Hydrocarbon
Low concentrations of pharmaceuticals: action and reaction of freshwater invertebrates – Pharma_CARE
Currently, more than 3000 active ingredients (APIs) are used for medical and veterinary purposes. Of a very varied nature, they are logically detected in the environment, with the contamination of aquatic ecosystems now established worldwide. By definition, these APIs are biologically active at low
Assessment of the effects of ionizing radiation in bees – BEERAD
The risk assessment linked to the radiocontamination of the environment after a nuclear accident is a major ecological issue but is still surrounded by controversial results and conclusions on the real impact of such events on flora and fauna inhabiting the targeted zones. Moreover, the potential un
Availability and transfer of trace elements through Arctic terrestrial food-chains and their health implications to large Arctic wildlife (ATCAF) – ATCAF
The Arctic is one of the planet’s most rapidly warming regions, which will likely alter the biogeochemical processes involved in the bioavailability and transfer of essential (i.e. nutrients such as Cu, Zn, Se) and non-essential (i.e. contaminants such as Pb, Cd, Hg) trace elements. Simultaneously,