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Aluminum-hydroxide-based adjuvants can absorb protein antigens from an aqueous solution and it is these adjuvants, as well as those based on aluminum phosphate, that are now widely used in vaccine formulation because of their immunostimulant behavior. The limited data in the literature show that the

The NanoSCAPE project aims to develop a new analytical methodology based on the use of nanoparticles and spectrometry techniques for the very high sensitive detection of bacteria and pathogens. The use of spectrometrically revealed nanoparticles will allow the direct detection of bacteria with extre

Chirality, or the "handedness" of chemical substances, has fascinated scientists since Pasteur first noticed that tartaric acid extracted from wine yeast rotated polarized light, while the same molecule synthesized in the lab had no such effect. The structural properties of chiral molecules play an

Secondary Organic Aerosol (SOA) particles in the atmosphere are recognized to affect both climate change and human health. Biogenic SOA (BSOA), which constitutes 30 to 50 % of the global organic aerosol budget, may be present in various particle phase states. To date, the formation and evolution (i.

Operando coupling of Steady-State Isotopic Transient Kinetic Analysis (SSITKA) and Fourier Transform InfraRed (FTIR) spectroscopy has evolved as one of the most powerful combination to investigate reaction mechanisms under real conditions. Information regarding catalytic surfaces, active sites and t

A fundamental goal of biophysical chemistry is to understand how physiological environments modulate the dynamics of proteins and, consequently, their function. In particular, we are interested in cellular membraneless organelles (MLOs). MLOs are delineated by liquid-liquid phase separation, often i

The textile industry is considered responsible for 4% of the global greenhouse gases emissions. Among the whole manufacturing process, dyeing steps are the most impacting ones: each year, over 100 million tons of fibres are manufactured requiring about 2 million tons of dyes, thus generating a consi

Protactinium, a radioelement with unknown chemistry, is a key element : first actinide for which the 5f orbitals can be involved in chemical bonding, it is also naturally ocurring in envrionment, in the nuclear fuel cycle and also appear in the synthesis of innovative isotopes for medicine. Understa

The chemical interactions between the oak wood of the barrels and brandies are of high interest for the best possible understanding of the evolution over time of the products which are put to age in the barrels, as well as the control and the optimization of their taste qualities. On the one side mo

The classical nucleation theory was recently challenged by the observation of stable and soluble pre-nucleation species (PNS) prior to formation of many solid materials. This suggests non-classical crystallization pathways (NCP) as key route towards various chemical architectures. However, the quasi

Carbohydrates are highly important biomolecules in living organisms, with by far the huge molecular diversity. Their structural deciphering represents a challenging task reflecting a strategic priority of the Glycosciences. In most cases, their actions are achieved by a more or less specific protein

By introducing a new paradigm for filtration, the DIADEM project aims at developing analytical devices for high throughput (> 1ml/min), “membraneless” sieving of colloidal suspensions having a wide range of characteristic sizes (from 10 nm to 10 µm), shapes and compositions (from synthetic particle

Many important biological and biotechnological phenomena depend on the assembly of small biomolecular building blocks into larger structures. These structures can be formed by biomolecules alone, as is the case in natural biological processes, or with the inclusion of nanoscaffolds such as quantum d

This research proposal aims to achieve a breakthrough in nuclear magnetic resonance (NMR) applications by advancing dynamic nuclear polarization (DNP)–a powerful sensitivity enhancement method–to high magnetic fields and at near ambient temperatures. NMR is a non-invasive technique that can provide

The ZEPHIRS consortium (ISMO, SOLEIL and ISM) proposes a double experimental approach allying the benefits of synchrotron and laser-based photoelectron spectroscopies to address the major issue of isomer/conformer identification of reactive intermediates relevant for atmospheric chemistry. The compl

Intrinsically Disordered Proteins (IDPs) play key roles in protein interaction networks and their dysfunctions are often related to severe diseases such as cancers or neurodegenerative diseases. Defined by their lack of stable secondary and tertiary structures in physiological conditions, these prot

We present a methodological development for glycomics - a field which lags far behind its counterparts genomics and proteims in terms of available analytical tools. The proposed method will focus on profiling glycans epitopes (acetylated sialic acid and sulfatated extremities) which is currently bey

Phosphorescent transition metal complexes (TMCs) possess appealing properties encompassing outstanding photo- and electro-chemical features, highly tunable emission color and relatively long-lived excited states. To date, the vast majority of TMCs used as dopant in light-emitting devices are either

The LANTEN project at the interface of chemistry, physics and biology, aims to design new lanthanide luminescent bioprobes (LLB) for two-photon (2P) microscopy bioimaging and simultaneously explores unprecedented diagnostic applications. The main originality of these probes is to target new biologic

The project nano-WAC aims to develop a new miniaturized affinity chromatography-based technology (nano-WAC) that will enable the innovative ligand-screening against native membrane proteins (MPs), notably G protein–coupled receptors (GPCRs), a large family of MPs with a tremendous clinical potential

G quadruplexes (GQs) are non-canonical nucleic acid structures that consist of at least two stacks of G quartets held together by stacking interactions, Hoogsteen base pairs and cation binding. GQ topologies can be categorized based on the relative direction of their four strands. RNA GQs mainly ado

Many devices of interest to sustainable chemistry and climate change have functions that depend on the underlying materials, ranging from the average long-range structure, down to more local environments of specific atoms and ions, whether the structure is ordered/disordered, and whether it is dynam

Carbohydrates, the most abundant and widespread biomolecules, present a remarkable diversity in chemical structures that results in even more diverse and complex higher-order structural features, from molecular conformations and interactions to assembly and packing manners. Many biological and mater

Short-wave infrared range (SWIR, “extended NIR”, ca. 1000 to 2500 nm i.e. 10000 to 4000 cm-1) has a great potential for the characterization of art paintings, and in particular for the non-invasive identification of binders and organic materials, which is crucial for the authentication of works of a

NADPH oxidases are unique enzymes producing superoxide to destroy pathogens. Flavocytochrome Cyt b558 is the core protein which is inserted in the membrane of phagosomes and catalyses the last step of superoxide production. The latter consists in the transfer of two electrons from a reduced flavin e

INFLOW assembles an interdisciplinary team at the interface between chemistry, fluid mechanics and Earth sciences to explore how multiphase flows of water and air control the chemical reactivity at mineral surfaces in unsaturated porous media. These dynamics play a central role in the transport and

Many microscopy techniques provide images for which contrast is brought by the measurement at each pixel of a molecular signature, like in multiplexed and hyperspectral imaging, or fluorescence lifetime imaging. For most biological/chemical systems, microscopy data can be decomposed into relatively

Recently, the induction of chirality on an achiral polar solvent by a chiral organic molecule has been observed in Raman Optical Activity (ROA) spectra. Several interpretations have been recently advanced, such as the intertwining of Raman Optical Activity and Electronic Circular Dichroism (ECD) eff

We propose a joint experimental-theoretical project to study the ultrafast electron migration induced by attosecond extreme ultraviolet radiation pulses and the following charge transfer including proton transfer in biomolecules, such as Glycine and uracilderivatives. Our general aim is to investiga

Hydrogen-deuterium exchange mass spectrometry (HDX/MS) is a popular analytical tool to study proteins dynamics, but in the field of nucleic acids, in-solution HDX/MS is currently not exploited. However, preliminary results show that nucleic acids are amenable to HDX/MS, opening new avenues to explor

The MoMoPlasm project targets the modeling, with electronic structure methods, of (i) the localized surface plasmon resonance (LSPR) taking place in noble metal nanoparticles, and (ii) its coupling with organic chromophores. Spanning from developments to applications, it plans to study at quantum ch

Monoclonal antibodies (mAbs) are considered as the most rapidly growing class of therapeutics to treat several diseases such as cancer, cardiovascular disorders, asthma, or autoimmune diseases. The therapeutic efficiency of mAbs relies mainly on their high target specificity, long circulating half-l

Glycosylation is a post-translational modification regulated by enzymes, which activity and expression level are affected by physiological and pathological conditions. Therefore, the study of their structure, the primary sequence of the protein associated to the sugar chain composition is an importa

The GROWNANO project aims at investigating the incorporation of metals in the gas-phase formation of carbon-rich dust as well as the role of metals in the growth of large carbon molecules via the chemistry of organometallic clusters. The central motivation for this project is related to stardust, it