Search

Presbyopia is the loss of accommodation affecting any individual after the age of 45 and preventing close reading. Although its consequences have been known and corrected by converging glasses since antiquity, biological aging, which modifies the biomechanics of the lens and makes it lose its flexib

The Global Burden of Disease Study reports around 4 million deaths each year worldwide for inflammatory lung diseases, the large proportion of which occurring in low- and middle-income countries. Inflammatory lung diseases include asthma, chronic obstructive pulmonary disease (COPD), pulmonary fibro

The PhLEs-NID project proposes to develop a non-invasive device in response to the problem of swallowing disorders. This device will combine several sensors capable of detecting different types of signals related to pharyngolaryngeal functioning. Thanks to their treatment by artificial intelligence,

Line-field Confocal Optical Coherence Tomography (LC-OCT) is an imaging technique invented by A. Dubois (project coordinator) and developed by DAMAE Medical for non-invasive in situ skin cancer diagnosis by providing a comprehensive cellular mapping of skin lesions based on morphological information

With population ageing worldwide, there is a constant increase in need for bone filling material in order to treat critical bone defect. Actually long bone defects are particularly challenging for regenerative medicine. To date, no adequate scaffold able to promote tissue ingrowth within such a cont

Wireless ingestible devices can non-invasively access major organs along the gastrointestinal tract for diagnosis and therapy. Recent advances in sensors and electronics permit microdevices that can sense their environment, release drugs, and perform biopsies, but existing wireless solutions remain

Cancer is one of the leading causes of death in the world. Its treatment relies on three well established pillars (surgery, radiation therapy, and chemotherapy) and several highly promising approaches such as immunotherapy. In the last decade, local therapies, based on thermal ablation or cryoablati

About 466 million people worldwide suffer from hearing loss. Of these, 34 million live in the EU and 6 million in France. With the aging of the world's population, this number is expected to increase to 900 million by 2050, WHO says. Still according to the WHO, disabling hearing loss can lead to dep

Human traumatic spinal cord injury (SCI) can lead to permanent loss of sensation and voluntary motor functions of patients, whose life-long disability is a major public health issue. Despite clinical advances in rehabilitation and neuromodulation treatment improving their quality of life, patients s

This project aims at developing a multi-material bioprinting platform involving microfluidics and integrated optics concepts to create heterogenous 3D models of tissues. The system will be adapted for the 3D assembly of different biological building blocks consisting of biomaterials mimicking the ex

One of the goals of Synthetic Biology is to build therapeutic bacteria that can target and treat pathologies, such as cancer, in vivo. Several such innovations are on their way: they empower the design of advanced synthetic biology to transform bacteria as therapeutic sensors and effectors in comple

Schistosomes are blood-dwelling parasites causing Schistosomiasis, or Bilharzia, the second most important parasitic disease after malaria. It affects 230 million people and is responsible for about 200 000 deaths per year. The pathology of schistosomiasis is mainly due to eggs in host tissues. Thes

The detection of consciousness in coma patients is a major clinical issue in critical care (ICU). Sound stimulation holds tremendous promise to reach to these patients but, despite much research, it remains plagued with critical limitations. Project Sounds4Coma brings together academic and medical e

Over the last decade, recurrent disease outbreak induced an ever-increasing demand upon cost reduction and improved security of diagnosis/prognosis making tools. The aim of the CAREFAB project is to develop a fully printable microfluidic paper-based device (µPAD) for multiplexed blood group genotypi

High-resolution EEG (HR-EEG) in preterms and magnetoencephalography (MEG) in foetuses (fMEG) have been developed in Inserm 1105 and in the fMEG center in Tubingen, respectively, providing access to the abilities of the immature network from the last trimester of gestation in and ex utero. We will an

Silicon carbide (SiC) is proposed as material to develop single material BMIs addressing the issue of their low lifetime. SiC is a biocompatible semiconductor, stiff material and therefore highly flexible for small thickness (

Vision restoration and visual rehabilitation could greatly benefit from eye movement analysis, but current eye-tracking solutions are not well suited to these patients. RE-SEE's objective, in this context, was to exploit the potential of a laser pointer embedded in a contact lens (CLP), recently dem

The AAC4All project aims at improving Augmentative and Alternative Communication (AAC) systems. AAC concerns a wide range of disabilities combining an inability to conduct oral communication with severe motor difficulties in using digital devices. The project brings together a multidisciplinary team

Knowledge of the electrical properties (EP, conductivity and permittivity) of human tissues is required to estimate, by numerical simulation, the heating of tissues during an MRI examination in the presence of implanted or accessory medical devices. Currently, simulations assume that EP values in a

Like RNA vaccines, our CRISCOFET proposal is revolutionary: it does not need gene amplification. CRISCOFET combines five recent technologies, CRISPR/Cas (clustered regular interspaced short palindromic repeats), EGOFETs (electrolyte-gated organic field-effect transistors), xurography, printed CMOS a

Total Hip Replacement (THR) is considered as the “surgery of the century”. The main cause is osteoarthritis (93%) which is prevalent in 11% of women and 9% of men. Moreover, age is one of the most important risk factors for osteoarthritis. In France, THR is the most common surgery with around 150 00

The Acute Respiratory Distress Syndrome (ARDS) is the most severe form of acute respiratory failure. It is currently highlightened by the Covid-19 crisis but, independently from this specific pandemic, it represents a constant public health issue. Despite precise recommendations for the implementati

Osteoarthritis (OA) is the most frequent joint disease in adult. It is responsible for disability and increased mortality. There is no efficient treatment and OA leads to cartilage degradation and joint destruction. Cartilage calcification favors cartilage degradation and worsens OA disease. It is c

The advent of human induced pluripotent stem cell (hiPSC) technology revolutionized the entire field of therapy development for cardiac diseases such as dilated cardiomyopathies. Cardiomyocytes derived from hiPSCs (hiPSC-CMs) are now at the basis of a growing number of platforms dedicated to perform

Today, according to various reports analyzing the medical device market, those related to orthopedic surgery are growing rapidly and will represent more than 22.4 Billion US dollars in 2025. Joint prostheses (hip, knee, hip) account for nearly 37% of the market share. These devices include conventio

Regenerative medicine is coming of age and preclinical studies are currently leading worldwide –including in France- to clinical trials in a diversity of applications of substitutive cell/tissue therapies. Nevertheless, one major roadblock is hampering progress toward expansion of that new form of m

Nearly 500,000 people suffer a spinal cord injury (SCI) every year, with dramatic human, societal, and economic costs. In the most severe cases, SCI leads to complete paralysis of both legs, forcing patients to remain in a wheelchair for the rest of their lives, with no prospect of treatment. Recen

Single-cell analysis has become an indispensable tool to overcome the cellular heterogeneity of healthy and diseased tissues. Indeed, the bulk analysis of a set of cells cannot give the complete picture of its heterogeneity. Tumors typically comprise multiple types of tumor cells in addition to a wi

Novel radio-isotopes are important in nuclear medicine to increase possibilities of imaging/therapies, and to better personalize treatments to the different patients. Their development is strongly constrained by the possibility of producing them in sufficient quantity with high chemical and isotopic

The innovative Opaque-Technology (OTech) derived from the LiquidO detection opens an unprecedented synergy between leading experts in medical and neutrino here proposing a new paradigm for medical imaging based on high precision antimatter ß+ detection. We propose to construct the first opaque liqui

The intracardiac blood flow vortex that forms during diastole, measured by 4D-CMR (cardiac magnetic resonance, 4-D = 3-D + time), reflects the filling capacity of the left heart. Since intracardiac blood flow imaging by CMR cannot be used in clinical routine, a fast and 100% clinically compatible ec

This project proposes a novel molecular architecture, based on trifluoroborate-functionnalized polyazamacrocycles, for the preparation of smart fluorinated tracers in theranostics and medical imaging. This single molecular design will tackle two important challenges in cancer research and in the cli

For a long time, the gold standard for artificially inducing brain activity was through electrical deep brain stimulation (DBS). This technique has been widely utilized for management of several diseases or neurological nature (Parkinson’s disease, pain, epilepsy). However, electrical stimulation te

Inflammation is the resulting cellular and tissue response to an aggression, whether due to an infection (bacterial or viral), an injury, an auto-immune disease, or a yet unidentified agent (Behçet’s disease). Blood vessels are in first line when an inflammatory process is triggered because they are

MRI has become an essential tool in the diagnosis of brain diseases, yet, faint or localized tissue alteration (lesions) can remain invisible, even with state of the art 3T MRI machines. The three-fold increase in signal to noise ratio offered by 7T MRI machines is an asset to surpass the image reso

The project DILI-on-chip addresses the development of a microfluidic device to assess in vitro adverse drug reactions, on a human-like liver lobule. We will focus on the particular case of DILI (drug induced liver injury). From a unique donor, hiPSCs (human induced pluripotent stem cells) will be di

Every year, there are 140 000 new cases of the acute vestibular syndrome (AVS), 28000 of which were caused by a carotid plaque rupture resulting in a stroke. The current medical recommendation only considered the stenosis degree of the carotid artery to define a surgical treatment to restore the art

Pancreatic cancer is a complex and progressive disease, for which advanced in vitro models are needed to enable decrypting of its initiation and progression mechanism. We have previously shown that bioprinting, an advanced biofabrication technology, is a key tool that enables the fabrication of near

Our first goal is to obtain highly stable collagen biomaterials with mechanical properties that resemble that of healthy cartilage, using a novel photocrosslinking method. This approach relies on the use of photoreactive groups, Diazirines, that readily react with the collagen backbone upon UV expos

Obsessive-Compulsive Disorder (OCD) is a disabling mental disorder featuring obsessions and compulsions. Current best medical practice for treating OCD involves a combination of medications and behavioral and cognitive therapy, and deep-brain stimulation as an alternative for the most severe cases.

In the last decade, the development of organoids has generated real enthusiasm, allowing the study of new treatments and the implementation of a personalized medicine approach while reducing experiments on animals. The generation of bone organoids from human mesenchymal stem cells capable of mimicki

The objective was to develop a viscoelastic hydrogel based on chitosan (CHT) and cyclodextrin polymers (PCD) with sustained release of an active ingredient, in order to develop an injectable medical device for active viscosupplementation and to ensure, 1) lubrication of the temporomandibular joint (

The cardiac conduction system (CCS) enables electrical impulses throughout the heart and initiate cardiac contraction. The architecture of CCS has been implicated in ventricular fibrillation which is the leading cause of sudden cardiac death in the industrialized countries. 3D imaging of CCS is ther

The cornea is a unique tissue featuring several important physiological properties, mainly transparency and refraction, related to crucial biomechanical properties. It exhibits a viscoelastic behaviour which is important for maintaining the corneal curvature despite changes in intraocular pressure (

Rational: Venous thromboembolism (VTE), clinically presenting as deep vein thrombosis (DVT) or pulmonary embolism (PE), is the third most frequent acute cardiovascular disease after myocardial infarction and stroke, and is associated with high mortality (around 10%). The frequency and the severity o

The aim of this project is to develop a ground breaking holographic label-free 3D time-lapse microscope to follow the development of living embryos directly in an incubator. Our device will measure original physiological parameters to identify new markers of mammalian preimplantation embryonic healt

Gastrointestinal cancer is a major public health problem worldwide. In France, there are 40,500 new cases of colorectal cancer (CRC) every year, with an incidence of 36 per 100,000 in men and 25 per 100,000 in women. It is the third most common cancer in the world. Early detection in gastrointestina

The RELIABLE project aims at developing an alternative method of detection for receptor-ligand binding assays in drug discovery. This method relies on the utilisation of lanthanide nanoparticles (NPs) as luminescent probe for the detection of very low-concentrated labelled ligand by time-resolved ph

Chronic diseases are responsible for deaths and quality of life impairment. Diabetes, for example, is affecting the daily life of patients that have to constantly follow up their glucose level to stave off dysglycemia episodes. On this ground, Continuous Glucose Monitoring systems (CGM) have recentl

The dura mater is the most external meningeal tissue (above arachnoid and pia mater) and consists of a half-rigid membrane located between the central nervous system (brain, spinal cord) and the surrounding bone tissue (skull, vertebrae). The dura mater is made of several layers of collagen fibres w

Functional mapping of the connectivity of the brain is an essential procedure for neurosurgeons aiming for maximal resection of a brain tumor, while minimizing damage to the eloquent cortex. Being able to delineate the location of critical cortical areas in individual patients allows the surgeon to

Wound healing is a major public health problem, and in France, 3% of the population suffers from chronic wounds that take from months to years to be cured and represent a handicap in everyday life. Most chronic wound patients either suffer diseases such as diabetes and obesity, or are of advanced ag

Photoacoustic imaging (PAI) is a biomedical imaging technique that provides optical contrasts at depth through the generation of acoustic waves with light. Handheld systems can be made for 3D navigation to image the vasculature and its oxygenation. However, these systems are impacted by limited view

Coronary microcirculation (i.e coronary flow in vessels smaller than 300µm) plays a key role in the control of cardiac perfusion. The importance of coronary microcirculation for relevant pathological conditions including angina in patients with normal or near-normal coronary angiograms is increasing

Current therapeutics of necrotic dental pulp consists of removing the tissue from the endodontic space and disinfecting and filling the emptied space, but the latter is very prone to bacterial re-colonization. DP regeneration strategies recently appeared to be promising, but they are hampered by res

The field of neurostimulation by low-energy ultrasound (LEUS) is an exciting and fast-growing field for the treatment of neurodegenerative and psychiatric disorders such as epilepsy, Parkinson’s disease, depression, among many others. LEUS is an attractive technology offering the ability to non-inva

The human body is daily exposed to vibrations of different nature. In the case of Manual Wheelchair (MWC) users, these vibrations are even present at the core of one's locomotion and, according to literature, have detrimental effect on their anatomical structures. Various parameters are likely to af

We will lift 3 main limitations hindering study of cellular heterogeneity relationship with microenvironment: measure population cell heterogeneity quantitatively, control the microenvironment, modulate cell microenvironment interactions. We choose ovarian cancer, since it is a representative model,