Search - Résilience - Coronavirus disease 2019 - 2021

In Spring 2020, the pandemic and the lockdown it led to gave birth to a large number of collect operations of traces of the event – photographs, stories, testimonies …. organized by cultural institutions and calling for citizen participation. Involving ordinary people in curating this « historical »

The Pandemic COVID-19 has impacted strongly habitual activities in numerous sectors, such as healthcare, business, social services and education. After two confinements and an ongoing curfew, a progressive return to a “normal” life might be promised by a massive vaccination system, even though the n

The fight against the Covid-19 epidemic is deployed on several fronts. In the field of care, this fight not only involves therapeutic advances, but also better care for the people affected. The objectives are to identify, based on the experience of patients hospitalized for Covid 19 at the Infectio

It is now widely accepted that households in poverty, and more generally households with the most precarious living conditions, are the hardest hit by the crisis caused by the Covid-19 epidemic, due to their greater exposure to health risks and to the economic and social consequences of this crisis.

Economists identify individuals’ psychology with their “social and economic preferences” (risk attitudes, time discounting, trust, cooperativeness, altruism, etc.), which were supposed to be stable over time. However, it has been shown that exposure to background risk can impact those preferences. I

During COVID-19 pandemia, the EFS contributes to the global effort of research to better understand this disease and to treat the most severe patients while decreasing the incidence and tension in hospitalisations. The CovidEP study (authorized by ANSM and CPP – HCL sponsor / Scientific coordination

Our proposal aims to monitor the ability of SARS-CoV-2 variants of concern, including South Africa, United Kingdom and Brazil ones, to infect human colonic organoid-derived cell monolayers, a model of choice to study host pathogen interaction in a standardized and reproducible way closely mimicking

Social cohesion is essential to the resilience of societies in the face of disasters (Motreff et al., 2018, Ungar et al., 2011). In the context of the Covid-19 pandemic, it is a necessary condition both for compliance to health recommendations during the crisis, and for society resilience in the aft

Since April 2020, a rare and life-threatening SARS-CoV2-related Kawasaki-like disease, designated by the CDC as Multisystem Inflammatory Syndrome in Children (MIS-C), emerged in communities with high rates of COVID-19, in particular in children. Available epidemiological data provided compelling evi

The mucosal immune response is the first line of defense in respiratory infections such as SARS-CoV-2. The COVIDIgS project aims to characterize the functional properties of this response and in particular the IgA response against SARS-CoV-2 variants. COVIDIgS benefits for this purpose from access t

Immunoglobulin A (IgA), the main antibody at mucosal surfaces, plays a crucial role in protecting the human host against infection by neutralizing viruses and impeding their attachment to epithelial cells. Consistent with the fact that SARS-CoV-2 spreads via the nasopharynx, SARS-CoV-2-specific IgA

A large part of the patients infected by the SARS-CoV-2 present persistent symptoms following the infection, sometimes several months after the initial symptoms onset. This is particularly the case for severe COVID-19 cases requiring hospitalization. Some studies show that around 75% of COVID-19 pat

SARS-CoV-2 is the human coronavirus that caused the pandemic that began in Wuhan, China at the end of 2019. This virus is the source of a contagious respiratory pathology known as COVID-19. The study of the first patients infected with severe forms of COVID-19 revealed an intense inflammatory respon

Systemic lupus erythematosus (SLE) is the most common chronic systemic autoimmune disorder, with 30000 patients followed in France. SLE patients are at increased risk of infections which are more frequent and severe both because of SLE disease itself and immunosuppressive drugs. A specific vaccinati

The COVID-19 epidemic represents a major threat to global health. This unprecedented health crisis has led many governments to set up a lockdown of their population to limit the transmission of the virus, as was the case in France, but not Sweden. Since the beginning of the COVID-19 epidemic, all ey

Few data are available on the impact of the epidemic and lockdown on suicide risk among students, either internationally or in France. Moreover, few studies have focused more specifically on healthcare students who represent a subpopulation that is probably even more at risk since many of them are,

On the basis of the two arguments developed, that the current situation is a unique opportunity to sustainably increase the modal share of cycling in urban transport systems and that the implementation of an efficient VLS system has a positive impact on the general development of cycling in urban ar

The definition of post-COVID syndrome is still not consensual. The French Health Authority (HAS) considers “long COVID” for patients with symptoms persisting for at least 4 weeks. It has published specific recommendations for the management of patients presenting long COVID forms. However, the Briti

It remains currently unknown precisely whether platelet activation contribute to the release of extracellular double-stranded DNA (dsDNA) during SARS-Cov-2 infection and severe acute lung inflammation. We hypothesized that platelet-derived cell-free DNA is recognized by the cGAS/STING pathway and ma

A series of studies converge in the finding that, during the Covid-19 emergency, compliance with the mandate to wear a face mask generally leads to lower compliance with the recommendation to keep a minimal physical distance from others. In the present state of knowledge, we know that this form of r

SARS-CoV-2, the etiological agent of COVID-19, infects lung epithelial cells and resident alveolar macrophages leading to lung injuries in patients with severe COVID-19, and triggering macrophage activation syndrome or "cytokine storm". Macrophages can be found in lungs as large multinucleated cells

Telework has experienced an unprecedented boom during the COVID-19 pandemic crisis. While it has had a protective effect on health and enabled those concerned to maintain their jobs, the specific context in which it was introduced may have exacerbated the potentially negative welfare effects of tele

The covid-19 pandemic has left, and continues to leave, numerous men and women prematurely and unexpectedly widowed. Surviving spouses must not only cope with the psychological consequences of bereavement, but also deal with greater economic hardship following partner loss. Especially younger widows

Although the COVID-19 pandemic peaked in March/April 2020 in France, the prevalence of infection is partially known as well as serological and local antibody response over time. We launched a study, called CURIOSA (NCT04369066), to collect and biobank sera from a large active and healthy population

The main aims of our project is to assess : 1. Attitudes towards vaccines and intention to vaccinate against COVID-19 in individual with schizophrenia compared to nonclinical participants 2. Competence to consent to COVID 19 vaccines in patients compared to nonclinical participants 3. Clinical,

INJUVID will study three significant domains of daily life – public space, family and work – in order to explore the ways in which both individuals and groups negotiate those tensions and disputes which have been exacerbated by measures to impede the spread of COVID-19, such as; lockdowns, curfews,

We focus on the impact of the Covid-19 crisis on hotels, restaurants, bars and fitness centers, specifically in terms of entrepreneurial fear of failure. Our main research objective is to better understand and assess this entrepreneurial fear of failure in terms of dimensions, antecedents and conseq

adaptation in the face of variability, re-elaboration of rules, development of individual and collective know-how, construction of professional sense, preservation of health. 3 main results: 1/ The resilience of the healthcare system depends on the collective ability to adapt, the re-organizations,

COVID-19 has led to exceptional measures, both health and legal, around the world. In France, the containment that began in March 2020 was the first step in a series of binding and extensive decisions applying to the entire population throughout the country, to contain the pandemic. These measures h

In this project we propose a human Intestinal model combining human primary cells (organoid derived) from colonic and small intestinal tissues with organ-on-chip technology to recapitulate the full hallmark of the small intestinal and colonic barrier (cells diversity, 3D topology, mechanical stimula

Several findings can now be made regarding the health of students in relation to the COVID-19 pandemic: 1. the majority of research is descriptive and does not identify the factors involved in the deterioration of students' health; 2. Studies have been conducted primarily during the first year of CO

Almost two years after the emergence of COVID-19, significant regional differences persist, showing the lowest incidence rates in sub-Saharan Africa, Southeast Asia, and Oceania. This trend was observed at the onset of the epidemic and has been confirmed during subsequent epidemic waves. Several

We conducted a prospective multicentre study including 11 intensive care units (ICU). Patients hospitalized in ICU with proven SARS-CoV-2 infection and acute respiratory failure requiring oxygen or mechanical ventilation support were included. Our objectives were to compare the mortality of patients

Young adults (aged 18-29) experience severe economic, psychological and associated social and health consequences from the COVID-19 pandemic. To advance evidence and to inform adaptive social, economic and public health responses, we are proposing to supplement our on-going multi-site mixed-methods

Almost 10% of patients with COVID-19 have persistent symptoms after resolution of the infection. Some of these symptoms are related to complications of hospitalization or to specific symptoms of COVID-19. However, the majority of patients display symptoms not present at the time of the acute infecti

In the context of the COVID-19 pandemic, vaccination plays a major role to reduce the virus circulation and the number of severe cases. However, the risk of severe allergic reaction, or anaphylaxis, reduce the access to vaccination. To date, the pursuit of vaccination is contraindicated for people w

Despite a growing number of publications, post-COVID-19 neurological disorders remain relatively little studied by magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) and their varied radiological semiology remains insufficiently described. It is important to evaluate the comp

The Covid-19 pandemic forced the reorganization of care including into maternity wards. It re-emerged the polemics on obstetric violence with the denunciation of two practices observed during childbirth in some establishments: the imposition of wearing the mask and the refusal to allow patients to b

By the end of 2021, there likely will be hundreds of millions of people infected with COVID-19 worldwide. The loss of smell (anosmia) will affect more than half of them. While most of them will rapidly recover their sense of smell, about 10% will not 6 months after the onset of the disease. Thus mil

Mental health consequences of the COVID-19 pandemic may be vast and may potentially overwhelm the mental health system in a long-lasting manner. Evaluating the effects of the COVID-19 pandemic on mental health in vulnerable groups such as children and adolescents has become an immediate priority. Th

The unprecedented spread of COVID-19 requires the development of fast and efficient diagnostic tools in order to stop the chains of contamination and to coordinate the actions at the national and international levels. Particularly, it concerns detection of SARS-CoV-2 and identification of its mutati

NEO-COV-AM aims at developing a pediatric non-human primate (NHP) model of SARS-CoV-2 infection. We will use this model to study the mechanisms of infection, focusing on dynamics of viral replication and mucosal immunity in the respiratory tract and at sites, which also exhibit high expression of AC

The outbreak of SARS-CoV-2, the etiological agent of COVID-1 is daunting and challenging event for the scientific community, health authorities and governments worldwide. Our understanding of the virus biology or the pathogenesis of the COVID-19 remains limited. In addition to the promise that vacci

The objective of the COVID-HEART project is to understand the pathophysiological mechanisms of long-term cardiometabolic complications in SARS-CoV-2 infection, aiming to identify predictive markers of these complications in COVID-19 patients. This project is related to the general thematic “Physiop