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Genotoxicity of chemical compounds is of high-concern in toxicology, and thus for human, animal and environmental health. Among short-term tests developed to assess the genotoxicity of compounds, the micronucleus (MN) assay is largely recognized as a reliable and precise method for detecting chromos

Les normes de migration actuelles permettent de vérifier la conformité de la quantité de polymère composant les contenants alimentaires qui passe vers son contenu (60mg de contenant/kg de denrée alimentaire). Aucune norme n’oblige à l’évaluation des effets biologiques des molécules composant les bar

The decline of pollinators is partly due to chemical inputs in the environment. The effects of these inputs on beneficial insects are most often evaluated by mortality tests, their impact on the physiology of insects at low doses remaining poorly understood. The most widely used insecticides (neon

The cause of Crohn's disease (CD) is unknown and there is no cure. The ambition of this project is to contribute to understanding the cause. We will investigate whether the presence of pollutants in the external environment is a risk factor for CD. Is there a link between environmental quality (air,

Seabirds are essential components of their Arctic marine ecosystems but are also particularly vulnerable to environmental modifications. Hence, seabirds are the most threatened group of birds in the world and their protection in the current context of climate change and increasing pollution risks ha

L'impact des pesticides sur la biodiversité et la santé est au cœur des débats, notamment dans les agroécosystèmes viticoles où les pesticides sont massivement utilisés. Notre projet vise à étudier les impacts des principaux pesticides utilisés dans les vignobles sur des vertébrés bioindicateurs de

L'objectif du projet INPAGE est d'étudier tout risque potentiel pour la sécurité alimentaire, lié à la dissémination des nanomatériaux dans l'environnement, et d'identifier les opportunités d'une approche « safer-by-design » dans la fabrication des particules de TiO2. Nous prévoyons d'étudier le tra

Les effets de ces différentes mutations sur le phénotype et la valeur sélective des vecteurs peuvent être variés et difficiles à anticiper, en particulier dans un environnement lui-même variable. Using interdisciplinary approaches, the ArchR project aims 1) to understand how these different genomic

Most of the published studies on nanoparticles toxicity towards microalgae focus on toxicity endpoints at the population scale, i.e. the contaminant inhibitory concentration determined by dose-dependent growth inhibition tests, at a given time. The objective of ANATOMIC is to get a deeper understand

Environmental pollutants and pathogens can have negative impacts on wildlife health and population dynamics. Individually, their effects may be small or sublethal, but little is known about the cumulative and interactive effects that can be generated when they are experienced together. The objective

Preliminary studies on MP in the atmosphere, in wet deposition (rain and snowfall) and in soils indicate that the atmosphere may play an important role in disseminating MP across the globe, including to remote areas such as the Arctic. The ATMO-PLASTIC project’s main objective is to fill this knowle

The catalytic region of the SDH is highly conserved across species: SDHI target mitochondrial functions that are not only critical in agricultural fungi, but also in all animals and plant species that have mitochondria. With respect to human health, genetic diseases and cancer genetics provide evide

This project aims to set up the placenta toxicology bases in response to two highly relevant contaminants from environmental pollution when they are encountered together in mixture: BaP and nanoceria. These two pollutants are contaminants to which pregnant woman and the unborn child are daily expose

The presence of inorganic nanoparticles (NPs) in common food additives (colourings, anti-caking agents) raises public health issues. Their size ( < 100 nm) allows NPs to cross biological barriers (intestine, placenta, blood-brain) until they contaminate the fetus, while their antibacterial propertie

Air pollution is a major public health concern in urban areas. Apart the direct consequences of air pollutant inhalation on cardiorespiratory system and premature death, it has been suggested that prenatal exposure to urban air pollutants is associated with an increased risk of developing autism or

Host microbiota is a key factor for animal health and its sensitivity to contaminants. The “Dyn-Microbiome” project will decipher the nature and role of host-associated microbiota in the modulation of contaminant toxicity for an aquatic sentinel animal, the Gammarus fossarum fresh-water amphipod, la

The Biocid@Home project brings together multiple disciplines (chemistry, hydrology, modeling, economics and social sciences) to characterize and reduce the health and environmental impacts of biocides. Biocides are contaminants of emerging concern that are widely used at home. Biocidal substances ar